Korean Circ J.  2003 May;33(5):439-445. 10.4070/kcj.2003.33.5.439.

The Inhibitory Effects of Platelet Glycoprotein IIb/IIIa Receptor Blocker-Coated Stent on Neointima Formation and Inflammatory Response in Porcine Coronary Stent Restenosis

• Park OY
• Jeong MH
• Kim JH
• Kim W
• Lee SH
• Hong YJ
• Kim JH
• Park WS
• Kim IS
• Choi MJ
• Ahn YK
• Park JT
• Cho JG
• Cho DL
• Park JC
• Kang JC

• KMID: 2093883
• DOI: http://doi.org/10.4070/kcj.2003.33.5.439

Abstract

BACKGROUND AND OBJECTIVES
Previously, we reported that Abciximab (ReoPro(r))-coated stent inhibited in-stent neointimal hyperplasia. ReoPro(r) is known to suppress vascular inflammation through CD 11b/18 (macrophage-1 receptor). We observed inhibitory effects of neointima formation and inflammatory reaction after stenting in a porcine model.
MATERIALS AND METHODS
The surface of the stent was coated with ReoPro(r) by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13) and ReoPro(r)-coated stents (Group II, n=13) in 26 porcine coronary arteries. Follow-up coronary angiogram and the histopathologic assessments of stented porcine coronary were performed on day 14 (Group I:n=6, Group II:n=6) and day 28 (Group I:n=7, Group II:n=7) after stenting.
RESULTS
Pathologic area stenosis was 19.7+/-5.3% in Group I and 15.9+/-3.3% in Group II at day 14, and 33.6+/-27.7% and 22.6+/-6.6%, respectively, at day 28 (p<0.05 at day 28). The ratio of inflammatory cells out of the number of total cells in the neointima was 21.8+/-6.5% in Group I and 22.5+/-11.6% in Group II at day 14, and 27.3+/-18.3% in Group I and 28.6+/-10.7% in Group II at day 28 post stenting (p=NS). And those of the media were 2.89+/-1.13% in Group I and 1.36+/-1.27% in Group II at day 14, and 6.61+/-5.61% and 6.26+/-4.51% at day 28 (p=NS). Fibrinoid materials associated with inflammatory reaction were observed in both groups at days 14 and 28.
CONCLUSION
An inflammatory reaction was not suppressed with the use of ReoPro(r)-coated stenting in a porcine stent restenosis model.

Keyword

Platelets; Stents; Coronary restenosis; Inflammation

MeSH Terms

Blood Platelets*
Constriction, Pathologic
Coronary Restenosis
Coronary Vessels
Follow-Up Studies
Glycoproteins*
Hyperplasia
Inflammation
Neointima*
Plasma
Polymerization
Polymers
Stents*
Transplants
Glycoproteins
Polymers