Korean J Otolaryngol-Head Neck Surg.
2000 Mar;43(3):282-285.
Expression of Human b-Defensin-1 mRNA in Human Nasal Mucosa
- Affiliations
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- 1Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul, korea. Sanghag@ns.kumc.or.kr
Abstract
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BACKGROUND AND OBJECTIVES:Antimicrobial peptides are cationic proteins that are found in a wide range of organisms. Recent reports suggest that human beta-defensin-1 (hBD-1), a prominent group of antimicrobial peptides, is an important component of the innate immune response, particularly at mucosal surfaces that are vulnerable to colonization by potential pathogens. Therefore, hBD-1 may participate in providing intrinsic nasal mucosal defense against microbial infections. The present study aimed to look for hBD-1 mRNA in apparently normal human nasal mucosa.
MATERIALS AND METHODS
The expression of hBD-1 mRNA was investigated in the inferior turbinate tissues using reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization.
RESULTS
The expression of hBD-1 mRNA was detected in these tissues. By in situ hybridization, hBD-1 mRNA was predominantly localized in superficial epithelial cells and submucosal glandular epithelium.
CONCLUSION
These data suggest that nasal epithelia and submucosal glands may secrete hBD-1 and thus contribute to the mucosal defense of the nose.
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