Korean J Anesthesiol.  2011 Dec;61(6):453-459. 10.4097/kjae.2011.61.6.453.

Dexmedetomidine is effective for monitored anesthesia care in outpatients undergoing cataract surgery

• Na HS
• Song IA
• Park HS
• Hwang JW
• Do SH
• Kim CS

• KMID: 1854056
• DOI: http://doi.org/10.4097/kjae.2011.61.6.453

Abstract

BACKGROUND
Dexmedetomidine has a sedative analgesic property without respiratory depression. This study evaluated the efficacy of dexmedetomidine as an appropriate sedative drug for monitored anesthesia care (MAC) in outpatients undergoing cataract surgery on both eyes compared with combination of propofol and alfentanil.
METHODS
Thirty-one eligible patients were randomly divided into two groups on the first operation day. Dexmedetomidine was administered in group D at 0.6 microg/kg/h, and propofol and alfentanil was infused concomitantly in group P at a rate of 2 mg/kg/h and 20 microg/kg/h, respectively. Sedation was titrated at Ramsay sedation score 3. Iowa satisfaction with anesthesia scale (ISAS) of the patients was evaluated postoperatively. Systolic blood pressure (SBP), heart rate (HR), respiration rate (RR), and peripheral oxygen saturation (SpO2) were recorded throughout the surgery. For the second operation, the group assignments were exchanged.
RESULTS
Postoperative ISAS was 50.3 (6.2) in group D and 42.7 (8.7) in group P, which was statistically significant (P < 0.001). SBP was significantly lower in group D compared with group P from the beginning of the operation. HR, RR, and SpO2 were comparable between the two groups. There were 8 cases (25.8%) of hypertension in group P, and 1 case (3.2%) in group D (P < 0.05). In contrast, 1 case (3.2%) of hypotension and 1 case (3.2%) of bradycardia occurred in group D.
CONCLUSIONS
Compared with the combined use of propofol and alfentanil, dexmedetomidine could be used appropriately for MAC in cataract surgery with better satisfaction from the patients and a more stable cardiovascular state.

Keyword

Cataract; Dexmedetomidine; Monitored anesthesia care; Propofol

MeSH Terms

Alfentanil
Anesthesia
Blood Pressure
Bradycardia
Cataract
Dexmedetomidine
Eye
Heart Rate
Humans
Hypertension
Hypotension
Iowa
Outpatients
Oxygen
Propofol
Respiratory Insufficiency
Respiratory Rate
Alfentanil
Dexmedetomidine
Oxygen
Propofol