J Korean Acad Rehabil Med.  2006 Apr;30(2):188-190.

A Case of Paraplegia Associated with Intrathecal Methotrexate : A case report

Affiliations
  • 1Department of Rehabilitation Medicine and Institute of Health Science, Gyeongsang National University College of Medicine, Korea. hsshin@nongae.gsnu.ac.kr

Abstract

The treatment and prophylactic therapy of meningeal leukemia with intrathecal methotrexate in acute lymphoblastic leukemia is the standard method. Intrathecal overdose of methotrexate may produce severe toxicities such as paraplegia. We experienced a case of paraplegia diagnosed by magnetic imaging examination of the spine in a 24-year-old woman received repeated intrathecal methotrexate for meningeal leukemia.

Keyword

Intrathecal methotrexate; Paraplegia; Meningeal leukemia

MeSH Terms

Female
Humans
Leukemia
Methotrexate*
Paraplegia*
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Spine
Young Adult
Methotrexate
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