Allergy Asthma Immunol Res.  2011 Jul;3(3):212-214. 10.4168/aair.2011.3.3.212.

Occupational Asthma Induced by the Reactive Dye Synozol Red-K 3BS

• Jin HJ
• Kim JH
• Kim JE
• Ye YM
• Park HS

• KMID: 1803328
• DOI: http://doi.org/10.4168/aair.2011.3.3.212

Abstract

Various reactive dyes can elicit occupational asthma in exposed textile industry workers. To date, there has been no report of occupational asthma caused by the red dye Synozol Red-K 3BS (Red-K). Here, we report a 38-year-old male textile worker with occupational asthma and rhinitis induced by inhalation of Red-K. He showed positive responses to Red-K extract on skin-prick testing and serum specific IgE antibodies to Red-K-human serum albumin conjugate were detected using an enzyme-linked immunosorbent assay. A bronchoprovocation test with Red-K extract resulted in significant bronchoconstriction. These findings suggest that the inhalation of the reactive dye Red-K can induce IgE-mediated occupational asthma and rhinitis in exposed workers.

Keyword

Asthma; reactive dye; occupation

MeSH Terms

Adult
Antibodies
Asthma
Asthma, Occupational
Bronchoconstriction
Coloring Agents
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin E
Inhalation
Male
Occupations
Rhinitis
Serum Albumin
Textile Industry
Textiles
Antibodies
Coloring Agents
Immunoglobulin E
Serum Albumin

Figure

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  Fig. 1 Chemical structures of Synozol RED K 3BS (A) and Synozol Black B 150 (B).

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  Fig. 2 Serum specific IgE levels to two reactive dye-human serum albumin conjugates by enzyme-linked immunosorbent assay: Synozol RED K 3BS (A) and Synozol Black B 150 (B). Horizontal bars indicate positive cut-off values. OD, optical density; NC, unexposed healthy controls.

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  Fig. 3 Results of bronchoprovocation tests with two reactive dye extracts: Synozol Black B 150 and Synozol RED K 3BS.

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