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Acute toxicity of benzalkonium chloride in Balb/c mice following intratracheal instillation and oral administration

Lee H, Park K

Benzalkonium chloride is a cationic surfactant widely used as a disinfectant, preservative, and sanitizer in many public places as well as domestically. The purpose of this study is to compare...
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Usefulness of serum lactate as a predictor of successful discontinuation of continuous atropine infusion in patients with severe acute organophosphate poisoning

Kwon HC, Cha YS, An GJ, Lee Y, Kim H

OBJECTIVE: In severe organophosphate (OP) poisoning, administration of atropine via continuous intravenous infusion is typically considered. To date, there have been no studies on predicting successful atropine discontinuation through plasma...
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Dyspnea Perception During Induced Bronchoconstriction Is Complicated by the Inhaled Methacholine in Children With Clinical Asthma

Choi YJ, Suh DI, Sohn MH, Koh YY

PURPOSE: Dyspnea is not widely utilized as an indicator of asthma provocation despite its universal presentation. We hypothesized that dyspnea severity was proportionate with the lung function decline, methacholine dose-step,...
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Respiratory Function and Symptoms Post Cold Air Exercise in Female High and Low Ventilation Sport Athletes

Kennedy MD, Faulhaber

PURPOSE: Cold weather exercise is common in many regions of the world; however, it is unclear whether respiratory function and symptom worsen progressively with colder air temperatures. Furthermore, it is...
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The KAAACI Standardization Committee Report on the procedure and application of the bronchial provocation tests

Lim KH, Kim MH, Yang MS, Song WJ, Jung JW, Lee J, Suh DI, Shin YS, Kwon JW, Kim SH, Kim SH, Lee BJ, Cho SH, Korean Academy of Asthma, Allergy and Clinical Immunology Standardization Committee

Bronchial provocation tests are of value in the evaluation of airway hyperresponsiveness. Nonspecific bronchial challenge (methacholine, mannitol, exercise, etc.) is used when the symptoms, physical examination, and measurements of pulmonary...
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Comparison on the profiles of a modified Borg scale and the pediatric dyspnea scale during an induced bronchoconstriction in children with clinical asthma

Kim YS, Shin J, Choi YJ, Song JH, Lee JK, Oh HL, Suh DI, Koh YY

PURPOSE: Dyspnea is the cardinal symptom of asthma, but it is difficult to quantify clinically. Although modified Borg (mBorg) scale has been successfully used in adult, but there has been...
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Is Performance of a Modified Eucapnic Voluntary Hyperpnea Test in High Ventilation Athletes Reproducible?

Kennedy MD, Steinback , Skow R, Parent EC

PURPOSE: Exercise-induced bronchoconstriction (EIB) is common in “high ventilation” athletes, and the Eucapnic Voluntary Hyperpnea (EVH) airway provocation test is the standard EIB screen. Although the EVH test is widely...
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Propranolol as a First-line Treatment for Pediatric Hemangioma: Outcome of a Single Institution Over One Year

Kim KM, Min DH, Jung HL, Shim JW, Kim DS, Shim JY, Park MS, Park HJ, Lee SY

BACKGROUND: Propranolol, a beta-blocker and well known anti-hypertensive medication, has been used as the first-line therapy for pediatric hemangioma since 2010. The objective of this study is to analyze the...
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The effects of daily bathing on symptoms of patients with bronchial asthma

Kamimura M, Arimoto Y, Homma C, Takeoka S, Fukusumi M, Mouri A, Hamamoto Y

BACKGROUND: The influence of bathing in asthma patients is not yet fully known. OBJECTIVE: We conducted an observational study to investigate changes in symptoms and their degree by bathing in asthmatic...
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A Case of Diffuse Neonatal Hemangiomatosis Successfully Treated with Propranolol

Jeong SY, Lee MJ, Yu J

We present a case of a 41-day-old girl with diffuse hemangiomatosis on her chin, right thigh, occipital area, and liver. She also had hepatomegaly, heart failure, and hypothyroidism. Hemangiomatosis did...
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Bronchoconstriction following instillation of phenylephrine eye drops in premature infants with bronchopulmonary dysplasia: two cases report

Kim HJ, Choi JG, Kwak KH

Premature infants requiring an ophthalmic examination or even surgery for retinopathy of prematurity (ROP) have a high prevalence of co-existing bronchopulmonary dysplasia (BPD). Reactive airway is one of the clinical...
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The role of leukotriene modifier in pediatric allergic disease

Choi BS, Sohn MH, Kim KE

Leukotriene (LT) modifiers are composed of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. LTs, C4, D4, and E4 are collectively termed cysteinyl LTs and best are the characterized receptors for cysLTs...
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The association of forced expiratory volume in one second and forced expiratory flow at 50% of the vital capacity, peak expiratory flow parameters, and blood eosinophil counts in exercise-induced bronchospasm in children with mild asthma

Akar HH, Tahan F, Gungor HE

BACKGROUND: Exercise-induced bronchoconstriction (EIB), which describes acute airway narrowing that occurs as a result of exercise, is associated with eosinophilic airway inflammation, bronchial hyperresponsiveness. The forced expiratory volume in one...
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Plasma secreted phospholipase A2 in asthmatic children: correlation with leptin levels and exercise induced bronchoconstriction

You JS, Choi WB, Yi YY, Jeong SI, Song JS, Yang S, Hwang IT, Lee HB, Baek HS

PURPOSE: Dysregulated cysteinyl leukotriene (CysLT) synthesis is prominent in exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 (sPLA2) plays a key regulatory role in the biosynthesis of CysLTs. We previously found that...
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Massive Cardiomegaly due to Dilated Cardiomyopathy Causing Bronchial Obstruction in an Infant

Lee JE, Oh JH, Lee JY, Koh DK

Dilated cardiomyopathy (DCMP) remains a life threatening disease in young patients and is often difficult to differentiate from myocarditis. Early recognition and treatment of DCMP are crucial for good prognoses...
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Relationship between duration of disease and bronchial responsiveness in 6-8 years old children with asthma

Shim E, Yu J

PURPOSE: Bronchial hyperresponsiveness is considered as a hallmark of asthma. The duration of asthma was demonstrated to be associated with bronchial responsiveness, expressed as methacholine PC20. We investigated the relationship...
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A Case of Bronchial Constriction Due to Buckwheat Allergy

Kim SY, Lee KS, Lee HL, Seo JH, Lee KE, Chung E, Lee SR

Buckwheat has been reported as a food allergen that can induce urticaria, angioedema and anaphylaxis. Moreover, it can cause occupational asthma and acute exacerbation in patients with asthma. Here, we...
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The effects of pycnogenol on antioxidant enzymes in a mouse model of ozone exposure

Lee MS, Moon KY, Bae DJ, Park MK, Jang AS

BACKGROUND/AIMS: Ozone is an environmentally reactive oxidant, and pycnogenol is a mixture of flavonoid compounds extracted from pine tree bark that have antioxidant activity. We investigated the effects of pycnogenol...
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Ratio of Leukotriene E4 to Exhaled Nitric Oxide and the Therapeutic Response in Children With Exercise-Induced Bronchoconstriction

Baek HS, Cho J, Kim JH, Oh JW, Lee HB

PURPOSE: This study assessed the association between the ratio of leukotriene E4 (LTE4) to fractional exhaled nitric oxide (FENO) in the response of children with exercise-induced bronchoconstriction (EIB) enrolled in...
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Airway Responses to Deep Inspiration in Asthma by Different Bronchial Challenge

Min CW, Jang AS, Ji YS, Cho NJ, Choi KH, Kwak YM

  • KMID: 2317651
  • Soonchunhyang Med Sci.
  • 2012 Dec;18(2):75-80.
OBJECTIVE: Deep inspirations (DI) provide physiologic protection against airway narrowing and DI-induced bronchoprotection and bronchodilation are impaired in asthma. METHODS: To evaluate effect of DI on airway narrowing during methacholine challenge,...
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