J Korean Med Sci.  2004 Dec;19(6):800-804. 10.3346/jkms.2004.19.6.800.

Production of Chemokines in Kawasaki Disease, Henoch-Schonlein Purpura and Acute Febrile Illness

• Chung HS
• Kim HY
• Kim HS
• Lee HJ
• Yuh JH
• Lee ES
• Choi KH
• Lee YH

• KMID: 1778559
• DOI: http://doi.org/10.3346/jkms.2004.19.6.800

Abstract

We compared the production of three chemokines; interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and growth-related onco-gene-alpha(Gro-alpha) that attracts monocytes or neutrophils, or both, in peripheral blood at acute stage of Kawasaki disease (n=29), Henoch-Schonlein purpura (n=15) and acute febrile illnesses (n=12). The production of the chemokines was assayed by ELISA. The plasma levels of IP-10 were markedly elevated in Kawasaki disease (538.6 +/-336.4 pg/mL) and acute febrile illnesses (417.1 +/-262.2 pg/mL) compared with in Henoch-Schonlein purpura (58.7 +/-95.7 pg/mL) (p<0.05). The MCP-1 levels were elevated in Kawasaki disease (443.0 +/-473.1 pg/mL) and acute febrile illnesses (328.6 +/-261.1 pg/mL) compared with in Henoch-Schonlein purpura (82.9 +/-79.0 pg/mL) (p<0.05). The Gro- levels were elevated only in acute febrile illnesses (134.3 +/-153.6 pg/mL) compared with in Kawasaki disease (31.8 +/-22.1 pg/mL) or Henoch-Schonlein purpura (29.4 +/-53.3 pg/mL) (p<0.05). According to these results, monocytes may play an important role in Kawasaki disease. In acute febrile illness-es, both monocytes and neutrophils may play an important role. By contrast, Henoch-Schonlein purpura may not be associated with the role of monocytes and neutrophils. Further studies using a larger number of cases are needed.

Keyword

Mucocutaneous Lymph Node Syndrome; Kawasaki Disease; Purpura, Schonlein-Henoch; Acute Febrile Illness; Measles; Gastroenteritis; Pneumonia; Tonsillitis; Mumps; Exanthem Subitum; Chemokines, CC; Chemokines, CXC; Chemokines

MeSH Terms

Acute Disease
Adolescent
Chemokines/*blood
Child
Child, Preschool
Comparative Study
Female
Fever/*blood/*epidemiology
Humans
Infant, Newborn
Korea/epidemiology
Male
Mucocutaneous Lymph Node Syndrome/*blood/*epidemiology
Purpura, Schoenlein-Henoch/*blood/*epidemiology
Research Support, Non-U.S. Gov't
Risk Assessment/methods
Risk Factors

Figure

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  Fig. 1 The chemokine IP-10 levels in plasma. KD, Kawasaki disease; HSP, Henoch-Schönlein purpura; AFI, Acute febrile illnesses.

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  Fig. 2 The chemokine MCP-1 levels in plasma. KD, Kawasaki disease; HSP, Henoch-Schönlein purpura; AFI, Acute febrile illnesses.

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  Fig. 3 The chemokine Gro-α levels in plasma. KD, Kawasaki disease; HSP, Henoch-Schönlein purpura; AFI, Acute febrile illnesses.

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