J Korean Med Sci.  2013 Nov;28(11):1697-1699. 10.3346/jkms.2013.28.11.1697.

Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy

• Nam YH
• Hwang EK
• Jin HJ
• Lee JM
• Shin YS
• Ye YM
• Palacin A
• Salcedo G
• Lee SY
• Park HS

• KMID: 1777673
• DOI: http://doi.org/10.3346/jkms.2013.28.11.1697

Abstract

Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical densityx1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.

Keyword

Baker's Asthma; Gliadin; Lipid Transfer Protein; Wheat

MeSH Terms

Adult
Anaphylaxis/immunology
Antigens, Plant/*immunology
Asthma/blood/diagnosis/immunology
Biological Markers/blood
Carrier Proteins/*immunology
Female
Gliadin/*immunology
Humans
Immunoglobulin E/*blood/immunology
Male
Phenotype
Triticum/immunology
Urticaria/immunology
Wheat Hypersensitivity/*diagnosis/*immunology
Antigens, Plant
Biological Markers
Carrier Proteins
Gliadin
Immunoglobulin E