Korean J Radiol.  2009 Aug;10(4):377-383. 10.3348/kjr.2009.10.4.377.

Cyst Ablation Using a Mixture of N-Butyl Cyanoacrylate and Iodized Oil in Patients with Autosomal Dominant Polycystic Kidney Disease: the Long-Term Results

Affiliations
  • 1Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Korea. radjycho@radiol.snu.ac.kr
  • 2Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 110-744, Korea.
  • 3Kidney Research Institute, Seoul National University Medical Research Center, Seoul 110-744, Korea.
  • 4Department of Radiology, Keimyung University College of Medicine, Dongsan Medical Center, Daegu 700-712, Korea.

Abstract


OBJECTIVE
We wanted to assess the long-term results of cyst ablation with using N-butyl cyanoacrylate (NBCA) and iodized oil in patients with autosomal dominant polycystic kidney disease (ADPKD) and symptomatic cysts.
MATERIALS AND METHODS
Cyst ablation using a mixture of NBCA and iodized oil was performed in 99 cysts from 21 patients who had such symptoms as abdominal distension and pain. The collapse or reaccumulation of the ablated cysts after the procedure was assessed during the follow-up period of 36 to 90 months. The treatment effects, including symptom relief, and the clinical data such as the blood pressure and serum creatinine levels were also assessed, together with the complications.
RESULTS
The procedure was technically successful in all 99 cysts from the 21 patients. Any procedure-related significant complications were not detected. Seventy-seven of 99 cysts (78%) were successfully collapsed on the follow-up CT. Twenty-two cysts showed reaccumulation during long-term follow-up period. The clinical symptoms were relieved in 17 of the 21 patients (76%). Four of 12 patients (33%) with hypertension and two of six patients (33%) with azotemia were improved. End stage renal disease (ESRD) occurred in six of the 21 patients (28%) during the follow-up period. The mean age of ESRD in our patients was 57 years. The mean time interval for the development of ESRD was 19 months.
CONCLUSION
Ablation using a mixture of NBCA and iodized oil may be an effective, safe method for obtaining symptom relief in patients with ADPKD.

Keyword

Kidney cyst; Autosomal dominant polycystic kidney disease; Cyst ablation

MeSH Terms

Adult
Aged
Enbucrilate/administration & dosage/*therapeutic use
Female
Follow-Up Studies
Humans
Iodized Oil/administration & dosage/*therapeutic use
Male
Middle Aged
Polycystic Kidney, Autosomal Dominant/*surgery
Sclerosing Solutions/administration & dosage/*therapeutic use
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