Korean J Nephrol.  2002 Jul;21(4):629-635.

Sclerotherapy of Renal Cysts in Korean ADPKD Patients

Affiliations
  • 1Department of Internal Medicine, Eulji Medical College, Korea.
  • 2Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea. curie@plaza.snu.ac.kr
  • 3Department of Internal Medicine, College of Medicine, Dankook University, Chonan, Korea.
  • 4Department of Biological Science, Sookmyung Womens University, Korea.
  • 5Clinical Research Institute, Seoul National University Hospital, Korea.
  • 6Department of Radiology, College of Medicine, Seoul National University, Seoul, Korea.

Abstract

BACKGROUND: Autosomal dominant polycystic kidney disease(ADPKD) is the most common hereditary renal disease in adults, and its major complaints include pain and abdominal fullness due to cyst expansion. So far, for the control of these symptoms, cyst ablation with ethanol or tetracycline, laparoscopic manipulations and surgical marsupialization have been used.
METHODS
We used conventional ethanol(n=9) or n-butyl cyanoacrylate(NBCA) plus lipiodol solution (n=18) or both(n=3) for separate cysts as the sclerosing agent in 24 adult Korean ADPKD patients. And their clinical courses after treatment were evaluated.
RESULTS
The male to female ratio was 8 : 16 and the mean age at the treatment was 50 yrs(S.D. 13.1). Causes for aspiration were pain in 14 and abdominal fullness in 7 patients and the range for the cyst diameters aspirated were 5-16 cm. Flank pain or discomfort were decreased subjectively in most cases except two. Mean arterial pressures(S.D.) (mmHg) before and after procedure were as follows 112(11.1)(basal), 96(9.6)(1 month) and 98(9.7)(6 month)(p < 0.05, paired-t test). Blood urea nitrogen levels(mg/dL) were not changed 6 month later[24 (12.1) vs. 22(14.6)]. There was no major complication such as bleeding or infection and no death and associated with procedure. There was no difference of therapeutic effect according to sclerosing agent.
CONCLUSION
NBCA was as effective as conventional ethanol for sclerotherapy in ADPKD and cyst ablation therapy showed a BP-lowering effect in short-term period.

Keyword

Autosomal dominant polycystic kidney disease; Sclerotherapy; ethanol; n-butyl cyanoacrylate

MeSH Terms

Adult
Blood Urea Nitrogen
Ethanol
Ethiodized Oil
Female
Flank Pain
Hemorrhage
Humans
Male
Polycystic Kidney, Autosomal Dominant*
Sclerotherapy*
Tetracycline
Ethanol
Ethiodized Oil
Tetracycline
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