Korean J Radiol.  2003 Dec;4(4):239-242. 10.3348/kjr.2003.4.4.239.

Ablation of Symptomatic Cysts Using Absolute Ethanol in 11 Patients with Autosomal-Dominant Polycystic Kidney Disease

• Lee YR
• Lee KB

• KMID: 1111253
• DOI: http://doi.org/10.3348/kjr.2003.4.4.239

Abstract

OBJECTIVE
To evaluate the effects of cyst ablation with absolute ethanol in autosomal-dominant polycystic kidney disease (ADPKD) patients with symptomatic cysts. MATERIALS AND METHODS: Using absolute ethanol, cyst ablation was performed in 11 patients with documented ADPKD who suffered cyst pain refractory to medical treatment. An ethanol solution was instilled into the largest symptomatic cysts through a catheter. We assessed the therapeutic efficacy of the procedure by tracking subjective pain relief during a 3 to 24-month follow-up period after ablation. RESULTS: At follow-up, we found that the duration of subjective pain relief was 12 to 24 months in seven patients, 4 to11 months in one, and less than 3 months in three. CONCLUSION: Selective ablation of a symptomatic cyst may be a valid option in managing chronic pain caused by one or a few large cysts in ADPKD patients.

Keyword

Kidney, cysts; Kidney, disease; Kidney, interventional procedures; Sclerotherapy

MeSH Terms

Adult
Aged
Contrast Media/administration & dosage
Ethanol/*therapeutic use
Female
Follow-Up Studies
Human
Male
Middle Aged
Pain, Intractable/etiology/physiopathology/*therapy
Palliative Care/methods
Polycystic Kidney, Autosomal Dominant/physiopathology/radiography/*therapy
Sclerotherapy/*methods
Solvents/therapeutic use
Tomography, X-Ray Computed
Treatment Outcome

Figure

• 

  Fig. 1 ADPKD in a 34-year-old man.A. Axial contrast enhanced CT scan depicts multiple cysts in both kidneys. An 8-cm cyst, present in the left kidney (arrows) was ablated.B. Sinogram obtained during sclerotherapy shows no evidence of extravasation or connection with the collecting system.C. Twelve-month follow-up CT reveals no evidence of re-expansion of the treated cyst. Pain was relieved for 18 months.

• 

  Fig. 2 ADPKD in a 52-year-old woman.A. Axial contrast-enhanced CT scan obtained prior to sclerotherapy depicts symptomatic cysts in both kidneys (arrows). Cyst ablation was performed bilaterally.B. Follow-up CT at 18 months shows reduced renal volume and no evidence of cyst re-expansion. Pain relief lasted 18 months.

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