Korean J Gastroenterol.  2013 Aug;62(2):104-110. 10.4166/kjg.2013.62.2.104.

Prevalence and Risk Factors of Colorectal Adenoma in 14,932 Koreans Undergoing Screening Colonoscopy

• Kim HS
• Baik SJ
• Kim KH
• Oh CR
• Lee SI

• KMID: 1775747
• DOI: http://doi.org/10.4166/kjg.2013.62.2.104

Abstract

BACKGROUND/AIMS
Current international guidelines recommend colorectal cancer screening for average-risk people over 50 years of age. Accordingly, we aimed to estimate the prevalence of colorectal neoplasms in all age groups and evaluate associated risk factors.
METHODS
Data of 14,932 subjects who underwent colonoscopy from July 2006 to January 2012 at Health Promotion Center, Gangnam Severance Hospital (Seoul, Korea) as part of a health check-up were reviewed retrospectively.
RESULTS
The overall prevalence of colorectal neoplasms and adenoma were 34.6% and 25.3%, respectively. Colorectal adenoma was found in 3.2%, 13.0%, 21.7%, 33.8%, 44.0%, 50.5%, and 54.2% of subjects under 30 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, 70-79 years, and over 80 years of age (trend p<0.0001). Independent predictors of colorectal adenoma included male gender (OR 2.38, 95% CI 2.084-2.718), positive occult blood (2.266, 1.761-2.917), positive serology of Helicobacter pylori (1.253, 1.114-1.409) and hypertriglyceremia (1.267, 1.065-1.508). Compared to the 30-39 years of age reference group, the ORs for each age group were 0.195 (under 30 years), 1.634 (40-49 years), 2.954 (50-59 years), 5.159 (60-69 years), 5.640 (70-79 years), 11.020 (over 80 years), while the 95% CIs were 0.071-0.536 (under 30 years), 1.340-1.992 (40-49 years), 2.421-3.604 (50-59 years), 4.109-6.476 (60-69 years), 3.822-8.322 (70-79 years), and 2.809-42.234 (over 80 years).
CONCLUSIONS
Colorectal adenoma prevalence increased proportionally with age. Only subjects under the age of 30 years had a definitely lower prevalence of colorectal adenoma. Male gender, positive occult blood, positive serology of H. pylori, and hypertriglyceremia were associated risk factors of colorectal adenoma.

Keyword

Colorectal adenoma; Helicobacter pylori; Occult blood; Triglycerides; Colonoscopy

MeSH Terms

Adenoma/*epidemiology/etiology
Adult
Age Factors
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Colonoscopy
Colorectal Neoplasms/*epidemiology/etiology
Female
Helicobacter Infections/complications
Helicobacter pylori
Humans
Hypertriglyceridemia/complications
Logistic Models
Male
Middle Aged
Odds Ratio
Republic of Korea/epidemiology
Retrospective Studies
Sex Factors

Figure

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  Fig. 1. Prevalence of colorectal polyp according to histology.

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  Fig. 2. Prevalence of colorectal adenoma according to age groups.

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  Fig. 3. Number of colorectal adenoma according to age groups.

Reference

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