Int J Oral Biol.
2014 Jun;39(2):87-95.
Identification and Antibiotic Susceptibility of the Bacteria from Non-odontogenic Infectious Lesions
- Affiliations
-
- 1Department of Oral & Maxillofacial Surgery, Dream Dental Clinic, Daejeon, Korea.
- 2Department of Dentistry, College of Medicine, Chungnam National University, Deajeon, Korea. hkkim4022@cnu.ac.kr
- 3Department of Nursing, Pai Chai University, Deajeon, Korea.
- 4Korean Collection for Oral Microbiology, Department of Oral Biochemistry, and Oral Biology Research Institute, School of Dentistry, Chosun University, Gwangju, Korea. jkkook@chosun.ac.kr
- 5Department of Dental Hygiene, Chunnam Techno University, Chunnam, Korea.
Abstract
- The purpose of this study was to isolate and identify bacteria from the 4 patients with non-odontogenic infectious lesions (mucormycosis, chronic inflammation from wound infection, and two actinomycosis) and determine their antimicrobial susceptibility against eight antibiotics. Bacterial culture was performed under three culture conditions (anaerobic, CO2, and aerobic incubator). The bacterial strains were identified by 16S rRNA gene (16S rDNA) sequence comparison analysis method. For investigating the antimicrobial susceptibility of the bacteria against eight antibiotics, penicillin G, amoxicillin, tetracycline, cefuroxime, erythromycin, clindamycin, vancomycin, and Augmentin(R) (amoxicillin + clavulanic acid), minimum inhibitory concentration (MIC) measurement was performed using broth microdilution assay. Nosocomial pathogens such as Enterococcus faecalis, Klebsiella pneumoniae, Bacillus subtilis, and Neisseria flavescens were isolated from mucormycosis. Veillonella parvula, Enterobacter hormaechei, and Acinetobacter calcoaceticus were isolated from chronic inflammatory lesion. Actinomyces massiliensis was isolated from actinomycosis in parotid gland. Capnocytophaga ochracea was isolated from actinomycosis in buccal region in anaerobic condition. There was no susceptible antibiotic to all bacteria in mucormycosis. Tetracycline was susceptible to all bacteria in chronic inflammation. C. ochracea was resistant to vancomycin and penicillin G; and other antibiotics showed susceptibility to all bacteria in actinomycosis. The results indicated that the combined treatment of two or more antibiotics is better than single antibiotic treatment in mucormycosis, and penicillin is the first recommended antibiotic to treat actinomycosis.
Keyword
MeSH Terms
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Acinetobacter calcoaceticus
Actinomyces
Actinomycosis
Amoxicillin
Anti-Bacterial Agents
Bacillus subtilis
Bacteria*
Capnocytophaga
Cefuroxime
Clindamycin
Enterobacter
Enterococcus faecalis
Erythromycin
Genes, rRNA
Humans
Inflammation
Klebsiella pneumoniae
Microbial Sensitivity Tests
Mucormycosis
Neisseria
Parotid Gland
Penicillin G
Penicillins
Tetracycline
Vancomycin
Veillonella
Wound Infection
Amoxicillin
Anti-Bacterial Agents
Cefuroxime
Clindamycin
Erythromycin
Penicillin G
Penicillins
Tetracycline
Vancomycin
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