Chonnam Med J.  2010 Aug;46(2):74-81. 10.4068/cmj.2010.46.2.74.

Clinical Effects of Statin in Elderly Patients with Acute Myocardial Infarction and Left Ventricular Dysfunction Who underwent Percutaneous Coronary Intervention

• Park DJ
• Jeong MH
• Park KH
• Sim DS
• Hong YJ
• Kim JH
• Ahn Y
• Cho JG
• Park JC
• Kang JC

• KMID: 1730002
• DOI: http://doi.org/10.4068/cmj.2010.46.2.74

Abstract

The purpose of the present study was to assess the clinical effects of statin on major adverse cardiac events (MACE) at the time of discharge in elderly patients with acute myocardial infarction (AMI) and with left ventricular dysfunction (LVD) who underwent percutaneous coronary intervention (PCI). The study was retrospective. One hundred seventy-nine elderly patients (> or =70 year-old) with AMI with LVD (ejection fraction< or =50%) who underwent PCI were analyzed out of AMI patients between 2006 and 2008. The patients were divided into two groups: Group I (n=137, 77.0+/-5.3 years, 81 males), who received statin before discharge, and Group II (n=42, 78.3+/-5.9 years, 22 males), who did not receive any statin. We performed a 6-month clinical follow-up after discharge. There were no significant differences in age, sex ratio, history of ischemic heart disease, blood pressure, heart rate on admission, ejection fraction, or prevalence of diabetes, hypertension, or dyslipidemia. According to the multiple logistic regression analysis, age was an independent predictor (p=0.003) and statin use significantly reduced 6-month MACE (p=0.037, OR=0.328, 95% CI: 0.115~0.933). No other factors were independent predictors of 6-month MACE. Statin therapy improves clinical outcomes in elderly AMI patients with LVD who undergo PCI.

Keyword

Myocardial infarction; Prognosis

MeSH Terms

Aged
Blood Pressure
Dyslipidemias
Follow-Up Studies
Heart Rate
Humans
Hypertension
Logistic Models
Myocardial Infarction
Myocardial Ischemia
Percutaneous Coronary Intervention
Prevalence
Prognosis
Retrospective Studies
Sex Ratio
Ventricular Dysfunction, Left

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