Korean J Parasitol.  2008 Mar;46(1):17-22. 10.3347/kjp.2008.46.1.17.

Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis

• Zhang H
• Chung BS
• Li S
• Choi MH
• Hong ST

• KMID: 1720545
• DOI: http://doi.org/10.3347/kjp.2008.46.1.17

Abstract

Rats develop strong resistance to re-infection and super-infection by Clonorchis sinensis. The present study investigated the antibodies present in the sera and bile juice of rats that were primary infected and re-infected with C. sinensis. The serum level of specific IgG antibodies, which were elevated 2 wk of the primary infection, peaked at 4 wk and subsequently remained unchanged even during re-infection. The total IgE level in serum increased slowly from 388 ng / ml to 3,426 ng / ml beginning 2 wk after the primary infection, and remained high up to 8 wk but dropped to a normal level (259 ng / ml) after treatment. In resistant re-infected rats, the serum IgE level increased rapidly and peaked within 1 wk, whereas no increase was observed in immunosuppressed rats. The serum level of specific IgA antibodies was elevated beginning 1 wk after infection, and decreased 4 wk after treatment. The total bile IgA level unchanged during the primary infection but increased in treated and re-infected rats. The elevated levels of serum IgE and bile IgA indicate that these immunoglobulins may be correlated with the development of resistance to re-infection by C. sinensis in rats.

Keyword

Clonorchis sinensis; Serum; Bile juice; IgA; IgE; Rat; Re-infection

MeSH Terms

Animals
Antibodies, Helminth/analysis/*blood/*immunology/metabolism
Bile/*immunology
Clonorchiasis/blood/*immunology
Clonorchis sinensis/*immunology/*physiology
Immunoglobulin A/analysis/blood
Male
Rats
Rats, Sprague-Dawley
Time Factors