Yonsei Med J.  2012 Jul;53(4):685-690. 10.3349/ymj.2012.53.4.685.

The Relationship between Coronary Artery Calcification and Renal Function in Nondialyzed Patients

• Chang JH
• Sung JY
• Jung JY
• Lee HH
• Chung W
• Sung YM
• Kim S

• KMID: 1716864
• DOI: http://doi.org/10.3349/ymj.2012.53.4.685

Abstract

PURPOSE
Coronary artery calcification (CAC) has been described in individuals with chronic kidney disease (CKD), and its presence is associated with an increased risk of cardiovascular death. However, it is unclear whether there is an independent relationship between renal function and CAC. Therefore, we evaluated the association between renal function and CAC.
MATERIALS AND METHODS
We retrospectively reviewed 870 Korean patients who had undergone computed tomographic coronary angiography. The glomerular filtration rate (GFR) was estimated using the Modification of Diet in Renal Disease study formula with an ethnic factor for the Korean population. The CKD stages were classified using estimated GFR (eGFR) and proteinuria.
RESULTS
The mean age of the participants was 56.8+/-11.8 years, and the mean eGFR was 89.4+/-16.5 mL/min/1.73 m2. Hypertension and diabetes were noted in 41.5 and 17.0% of patients, respectively. There were 584 and 286 patients with no CAC and with CAC, respectively. After adjusting for confounding variables, late stage CKD was associated with CAC [odds ratio (OR) 2.80, 95% confidence interval (CI) 1.05-7.46]. However, early stage CKD was not associated with CAC (OR 1.61, 95% CI 0.92-2.82). Diabetes was an independent risk factor of CAC (OR 2.06, 95% CI 1.36-3.13). There was no significant association between proteinuria and CAC (OR 1.65, 95% CI 0.96-2.85).
CONCLUSION
CAC is related to late stage CKD in nondialyzed patients. These findings emphasize that individuals with CAC should be considered a high-risk population for decreased renal function.

Keyword

Chronic kidney disease; coronary artery calcification; proteinuria; renal function

MeSH Terms

Aged
Chronic Disease
Coronary Artery Disease/*pathology/*physiopathology
Female
Glomerular Filtration Rate/physiology
Humans
Kidney Diseases/pathology/*physiopathology
Linear Models
Male
Middle Aged
Proteinuria/pathology/physiopathology
Renal Dialysis
Retrospective Studies
Risk Factors

Figure

• 

  Fig. 1 Distribution of coronary artery calcification (CAC) scores according to chronic kidney disease (CKD) stage. (A) All patients, (B) stratified by the presence of diabetes, and (C) stratified by the presence of proteinuria.

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