J Korean Neurol Assoc.  2014 Feb;32(1):34-37.

Paraneoplastic Necrotizing Myopathy Associated With Ovarian Adenocarcinoma

Affiliations
  • 1Department of Neurology, Korea University College of Medicine, Seoul, Korea. jhkim.merrf@gmail.com
  • 2Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
  • 3Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

We describe here a case of female patient who presented with mild proximal weakness, myalgia, and markedly elevated CPK, which could be ascribed to paraneoplastic necrotizing myopathy in association with ovarian adenocarcinoma. A histologic examination of the vastus lateralis muscle showed necrosis of muscle fibers without inflammatory cell infiltration. Her neurologic symptoms improved following tumor resection and systemic chemotherapy. Paraneoplastic necrotizing myopathy may be a presenting manifestation of malignancy, and early recognition and prompt treatment are crucial for the clinical improvement.

Keyword

Paraneoplastic myopathy; Necrotizing myopathy; Ovarian adenocarcinoma

MeSH Terms

Adenocarcinoma*
Drug Therapy
Female
Humans
Muscular Diseases*
Myalgia
Necrosis
Neurologic Manifestations
Quadriceps Muscle
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