Korean J Neuromuscul Disord.  2021 Jun;13(1):15-19. 10.46518/kjnmd.2021.13.1.15.

Statin-Naïve Paraneoplastic Anti-HMGCR Myopathy

Affiliations
  • 1Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea

Abstract

Anti-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (anti-HMGCR) myopathy is a subtype of immune-mediated necrotizing myopathy regardless of exposure to statins. Necrotizing myopathy is distinguished by necrotic muscle fibers with a relative lack of inflammation. It is frequently associated with a high risk of permanent muscle damage and disability. Recent studies have suggested a slightly increased risk of cancer in patients with anti-HMGCR myopathy. This report describes a case of statin-naïve paraneoplastic anti-HMGCR myopathy, with rapidly progressive muscle weakness leading to respiratory failure.

Keyword

Anti-HMGCR; Necrotizing myopathy; Statin-naïve
Full Text Links
  • KJND
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr