Korean J Physiol Pharmacol.  2004 Aug;8(4):173-179.

The Role of BF-7 on Neuroprotection and Enhancement of Cognitive Function

• Chae HS
• Kang YK
• Shin YK
• Lee HJ
• Yu JI
• Lee KG
• Yeo JH
• Kim YS
• Sohn DS
• Kim KY
• Lee WB
• Lee SH
• Kim SS

Abstract

Amyloid beta-peptide (A beta) contributes to the pathogenesis of Alzheimer's disease (AD), causing neuronal death through apoptosis. In this study, the neuroprotective role of BF-7, extracted form sericultural product, was examined against A beta -induced toxicity in cultured human neuronal cell SKN-SH. In order to know if the BF-7 has positive role on the cognition and memory in human, the mixture of BF-7, DHA and EPA (BDE) was examined using Rey Kim and K-WAIS test with 50 healthy high school student. We report here that BDE significantly attenuated A beta-induced apoptosis through the reduction of ROS accumulation, and diminished caspase-like protease activity. Moreover, the memory index and memory preservation, and attentative concentration of BDE treated group for 1 month were significantly improved, in contrast to the case of placebo control treated with DHA and EPA. This result represent that the BF-7 play significant positive role on learning memory. Taken together, our result suggested the natural product BF-7 is a good substance for the brain functionally and physiologically.

Keyword

Brain; Learning and memory; BF-7; Natural product; Amyloid

MeSH Terms

Alzheimer Disease
Amyloid
Amyloid beta-Peptides
Apoptosis
Brain
Cognition
Humans
Learning
Memory
Neurons
Amyloid
Amyloid beta-Peptides