J Korean Neurol Assoc.
2006 Jun;24(3):210-214.
The Change of PAC-1 and P-selectin Expression after Initiation of Antiplatelets in Patients with Acute Ischemic Stroke
- Affiliations
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- 1Department of Neurology, Soonchunhyang University College of Medicine, Bucheon, Korea. sapark@schbc.ac.kr
- 2Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea.
Abstract
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BACKGROUND: The purpose of this study was to evaluate the time course of PAC-1 and the P-selectin expression after the initiation of antiplatelets in acute ischemic stroke.
METHODS
We serially measured PAC-1 and the P-selectin expression level using flow cytometry immediately before and at: one day, seven days, and one month after starting antiplatelets in 25 patients with acute cerebral infarctions.
RESULTS
The P-selectin expression increased initially (p<0.05) and then from the seventh day, it began to decrease continually (post-hoc analysis, p<0.05). However, the PAC-1 expression did not reveal significant alterations during the follow-up period of one month.
CONCLUSIONS
Although the P-selectin expression rapidly declined, the PAC-1 expression remained elevated for one month. Our results suggest that the P-selectin may be useful in monitoring platelet inhibition during the early period after cerebral infarction.
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