- Significance of PD-L1 expression in carbon-ion radiotherapy for uterine cervical adeno/adenosquamous carcinoma
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Iijima M, Okonogi N, Nakajima N, Morokoshi , Kanda H, Yamada T, Kobayashi , Banno K, Wakatsuki , Yamada S, Kamada T, Aoki D, Hasegawa S
- KMID: 2470870
- J Gynecol Oncol.
- 2020 Mar;31(2):e19.
- doi: 10.3802/jgo.2020.31.e19
OBJECTIVE: Programmed cell death-ligand 1 (PD-L1) is expressed in tumor cells and has been shown to predict clinical outcomes of several types of malignancies. The aim of this study was... -
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- Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases: A Single Center Experience
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Kwon WK, Choi S, Kim HJ, Huh HJ, Kang JM, Kim YJ, Yoo KH, Ahn K, Cho HK, Peck KR, Jang JH, Ki CS, Kang ES
- KMID: 2468463
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):292-305.
- doi: 10.4168/aair.2020.12.2.292
PURPOSE: While there is an urgent need for diagnosis and therapeutic intervention in patients with primary immunodeficiency diseases (PIDs), current genetic tests have drawbacks. We retrospectively reviewed the usefulness of... -
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- 1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis
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Kim H, Baek S, Hong SM, Lee J, Jung SM, Lee J, Cho ML, Kwok SK, Park SH
- KMID: 2469943
- J Korean Med Sci.
- 2020 Feb;35(6):e40.
- doi: 10.3346/jkms.2020.35.e40
BACKGROUND: Immune cells express the vitamin (vit) D receptor, and vit D is a potent immune-modulator. A negative correlation between serum vit D levels and rheumatoid arthritis (RA) disease activity... -
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- MicroRNA-10b Plays a Role in Bone Formation by Suppressing Interleukin-22 in Ankylosing Spondylitis
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Park PR, Jo S, Jin SH, Kim TJ
- KMID: 2471963
- J Rheum Dis.
- 2020 Jan;27(1):61-67.
- doi: 10.4078/jrd.2020.27.1.61
OBJECTIVE: The microRNA (miR)-10b is the T helper (Th) 17 cell specific in patients with ankylosing spondylitis (AS). The interleukin (IL)-22, which is closely related to Th17 cells, has been... -
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- Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells
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Lee SE, Park HR, Jeon S, Han D, Park YS
- KMID: 2470810
- J Lipid Atheroscler.
- 2020 Jan;9(1):184-194.
- doi: 10.12997/jla.2020.9.1.184
OBJECTIVE: Inflammation is crucial to limiting vascular disease. Previously we reported that acrolein, a known toxin in tobacco smoke, might play an important role in the progression of atherosclerosis via... -
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- Bordetella bronchiseptica is a potent and safe adjuvant that enhances the antigen-presenting capability of dendritic cells
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Lee YJ, Han Y, Joo HG
- KMID: 2466569
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):47-52.
- doi: 10.4196/kjpp.2020.24.1.47
We previously demonstrated that Bordetella bronchiseptica (B. bronchiseptica) antigen (Ag) enhances the Mycoplasma hyopneumoniae Ag-specific immune response. The focus of this study was whether acellular bacterin of B. bronchiseptica could... -
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- Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
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Leem G, Kim BK, Shin EC, Park JY
- KMID: 2466342
- Yonsei Med J.
- 2020 Jan;61(1):100-102.
- doi: 10.3349/ymj.2020.61.1.100
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who... -
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- Circulating MicroRNAs and T-Cell Cytokine Expression Are Associated With the Characteristics of Asthma Exacerbation
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Wardzyńska A, Pawełczyk M, Rywaniak J, Kurowski M, Makowska J, Kowalski M
- KMID: 2462577
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):125-136.
- doi: 10.4168/aair.2020.12.1.125
PURPOSE: Immunological mechanisms underlying asthma exacerbation have not been elucidated. The aim of this study was to assess the associations of various asthma exacerbation traits with selected serum microRNA (miRNA)... -
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- JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma
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Kim MS, Park CJ, Cho YU, Jang S, Seo EJ, Park CS, Huh J, Im HJ, Seo JJ, Yoon DH, Suh C
- KMID: 2457486
- Ann Lab Med.
- 2020 Jan;40(1):1-6.
- doi: 10.3343/alm.2020.40.1.1
BACKGROUND: JL1, a CD43 epitope and mucin family cell surface glycoprotein, is expressed on leukemic cells. An anti-JL1 antibody combined with a toxic substance can have targeted therapeutic effects against... -
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- Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/β-Catenin Pathway
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Pei YY, Li GC, Ran J, Wan XH, Wei FX, Wang L
- KMID: 2470890
- J Breast Cancer.
- 2019 Dec;22(4):522-532.
- doi: 10.4048/jbc.2019.22.e51
PURPOSE: Our previous studies have shown that kinesin family member 11 (KIF11) is markedly overexpressed in human breast cancer cells or tissues and positively correlated with distant metastasis and prognosis... -
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- B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis
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Min YG, Park C, Kwon YN, Shin JY, Sung JJ, Hong YH
- KMID: 2468888
- Exp Neurobiol.
- 2019 Dec;28(6):720-726.
- doi: 10.5607/en.2019.28.6.720
Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that... -
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- Immunological Differences Between Right-Sided and Left-Sided Colorectal Cancers: A Comparison of Embryologic Midgut and Hindgut
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Kwak HD, Ju JK
- KMID: 2468857
- Ann Coloproctol.
- 2019 Dec;35(6):342-346.
- doi: 10.3393/ac.2019.03.17.1
PURPOSE: There are known differences in embryology, clinical symptoms, incidences, molecular pathways involved, and oncologic outcomes of right-sided and left-sided colorectal cancers. However, immunologic study has only been characterized for... -
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- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells
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Kim D, Kim Y, Kim Y
- KMID: 2468812
- J Cancer Prev.
- 2019 Dec;24(4):224-232.
- doi: 10.15430/JCP.2019.24.4.224
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have... -
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- Splenocyte-mediated immune enhancing activity of Sargassum horneri extracts
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Kim DS, Sung NY, Han IJ, Lee BS, Park SY, Nho EY, Eom J, Kim G, Kim KA
- KMID: 2466666
- J Nutr Health.
- 2019 Dec;52(6):515-528.
- doi: 10.4163/jnh.2019.52.6.515
PURPOSE: This study examined the immunological activity and optimized the mixture conditions of Sargassum horneri (S. horneri) extracts in vitro and in vivo models. METHODS: S. horneri was extracted using three... -
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- A Critical Role of PCSK9 in Mediating IL-17-Producing T Cell Responses in Hyperlipidemia
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Kim YU, Kee P, Danila D, Teng BB
- KMID: 2466611
- Immune Netw.
- 2019 Dec;19(6):e41.
- doi: 10.4110/in.2019.19.e41
We previously demonstrated that atherogenic Ldlr(−/−)Apobec1(−/−) (LDb) double knockout mice lacking both low-density lipoprotein receptor (LDLR) and apolipoprotein B mRNA-editing catalytic polypeptide-1 (Apobec1) had increased serum IL-17 levels, with T... -
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- Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation
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Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L
- KMID: 2463799
- Yonsei Med J.
- 2019 Dec;60(12):1195-1202.
- doi: 10.3349/ymj.2019.60.12.1195
PURPOSE: The aim of this study was to investigate whether propofol could attenuate hypoxia/reoxygenation-induced apoptosis and autophagy in human renal proximal tubular cells (HK-2) by inhibiting JNK activation. MATERIALS AND METHODS:... -
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- MiR-338-3p Enhances Ovarian Cancer Cell Sensitivity to Cisplatin by Downregulating WNT2B
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Niu Q, Liu Z, Gao J, Wang Q
- KMID: 2463793
- Yonsei Med J.
- 2019 Dec;60(12):1146-1156.
- doi: 10.3349/ymj.2019.60.12.1146
PURPOSE: Chemoresistance is a concern in ovarian cancer patients, in whom survival remains. MicroRNA, a novel class of small RNAs, have frequently been found to be dysregulated in human malignancies... -
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- Anti-cancer Activity of Paclitaxel, Lenvatinib and Radiation Combination Therapy on Anaplastic Thyroid Cancer in Vitro and in Vivo
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Jun S, Kim SY, Kim SM, Park KC, Kim HJ, Chang HJ, Lee YS, Chang HS, Park CS
- KMID: 2469230
- Korean J Head Neck Oncol.
- 2019 Nov;35(2):19-25.
- doi: 10.21593/kjhno/2019.35.2.19
BACKGROUND/OBJECTIVES: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at... -
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- Role of Immunosuppressive Microenvironment in Acquiring Immunotolerance Post-Photothermal Therapy
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Cherukula , Park MS, Sontyana A, Mathew AP, Vijayan V, Bae WK, Park IK
- KMID: 2462185
- J Korean Med Sci.
- 2019 Nov;34(44):e272.
- doi: 10.3346/jkms.2019.34.e272
BACKGROUND: Nanoparticle-mediated photothermal therapy (PTT) has been well studied as a treatment for cancer. However, the therapeutic outcome of PTT is often hindered by the penetration depth of laser light.... -
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- POEMS Syndrome: Bone Marrow, Laboratory, and Clinical Findings in 24 Korean Patients
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Shim H, Seol CA, Park CJ, Cho YU, Seo EJ, Lee JH, Yoon DH, Suh CW, Park SH, Jang S
- KMID: 2450951
- Ann Lab Med.
- 2019 Nov;39(6):561-565.
- doi: 10.3343/alm.2019.39.6.561
POEMS syndrome is a rare paraneoplastic syndrome, which includes polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes due to plasma cell (PC) neoplasm. Diagnosis of this disease is challenging because of... -
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