Korean J Otolaryngol-Head Neck Surg.  1998 May;41(5):620-625.

Expression of Cyclin D1 Protein and Ki-67 Index in Advanced Squamous Cell Carcinomas of Head and Neck and Correlation with Response to Chemotherapy and Radiotherapy

• Kim SH
• Choi BY
• Hwang DJ

Abstract

BACKGROUND AND OBJECTIVES: Although several oncogenes have been implicated in cellular resistance to ionising radiation or anticancer drug, there is little known about clinical information relating oncogene expression with clinical response to chemoradiotherapy. Correlation between expression of cyclin D1 and Ki-67 and clinical response to chemotherapy and radiotherapy in advanced squamous cell carcinomas was investigated. DESIGN: Retrospective study.
MATERIALS AND METHODS
Formalin-fixed, paraffin-embedded tumor materials of 36 patients with advanced SCC of head and neck (clinical stage III, IV) were analyzed by immunohistochemical method with cyclin D1 and MIB-1 monoclonal antibodies. All patients were treated with induction chemotherapy and 22 patients were followed by radiotherapy.
RESULTS
Overexpression of cyclin D1 protein was found in 33% (12/36). The expressed range of Ki-67 was from 0% to 80.1%. Expression of cyclin D1 protein was higher in the non-response group than in the response group to chemotherapy, but was not correlated with radiotherapy response. The Ki-67 index was not associated with tumor response to chemotherapy and radiotherapy.
CONCLUSIONS
These data suggest that overexpression of cyclin D1 would be a marker for the chemotherapy response, although not for the radiotherapy response, whereas Ki-67 index may not be associated with tumor response to the chemotherapy and not to the radiotherapy in advanced squamous cell carcinomas of head and neck.

Keyword

Cyclin D1; Ki-67; Chemotherapy; Radiotherapy; Head and Neck Squamous cell carcinoma

MeSH Terms

Antibodies, Monoclonal
Carcinoma, Squamous Cell*
Chemoradiotherapy
Cyclin D1*
Cyclins*
Drug Therapy*
Head*
Humans
Induction Chemotherapy
Neck*
Oncogenes
Radiotherapy*
Retrospective Studies
Antibodies, Monoclonal
Cyclin D1
Cyclins