J Rhinol.  2008 Nov;15(2):108-114.

Expression of p53, p21, Cycin D1, and Ki-67 in Sinonasal Tumors

Affiliations
  • 1Department of Otolaryngology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea. coolnose@wmc.wonkwang.ac.kr
  • 2Department of Pathology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea.

Abstract

BACKGROUND AND OBJECTIVES
The goal of this study is to investigate alterations of cell-cycle-related molecules, including p53, p21, cyclin D1 and Ki-67, in tumors arising in the sinonasal region. MATERIALS AND METHODS: The study materials were 16 specimens of normal nasal mucosa, 16 inverted papillomas (IPs) and 12 sinonasal squamous cell carcinomas. The p53, p21, cyclin D1 and Ki-67 expression was assessed by immunohistochemical staining. RESULT: IP and squamous cell carcinoma showed significant increase in the expression of p53, cyclin D1 and Ki-67 than normal mucosa. The expression of p53, cyclin D1 and Ki-67 of the carcinoma was stronger than the IP. But, the p21 expression was not associated with the IP and carcinoma. CONCLUSION: Increased levels of p53, cyclin D1 and Ki-67 expression correlate with increased cell proliferation in the tumors of sinonasal regions. These findings indicate that p53, cyclin D1 and Ki-67 expression may be useful markers for the dysregulations of cell kinetics in the tumors of sinonasal region.

Keyword

Inverted papilloma; Sinonasal squamous cell carcinoma; p53; Cyclin D1; Ki-67
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