Korean J Reprod Med.  2009 Sep;36(3):219-224.

Outcome of Gonadotropin Therapy for Infertile Men with Hypogonadotropic Hypogonadism

• Joo YM
• Kim TH
• Seo JT

Abstract

OBJECTIVE
Hypogonadotropic hypogonadism (HH) is an uncommon cause of male infertility. We investigated the outcome of gonadotropin therapy for restoring fertility and pregnancy outcomes in patients with HH.
METHODS
Medical charts of 10 infertile male patients with HH treated with gonadotropin were reviewed. Initial testicular volume were estimated. Semen analysis parameters (semen volume, sperm counts, motility), serum leutenizing hormone (LH), follicle stimulating hormone (FSH), total testosterone were determined before and after human chorionic gonadotropin/human menopausal gonadotropin (hCG/hMG) treatment. Differences were analyzed statistically.
RESULTS
Of 10 patients, 7 (70%) succeed at pregnancy (nature pregnancy in 4). Semen analysis parameters, serum FSH, and testosterone were increased significantly after treatment. The population was stratified according to initial testicular volume into a small testis subset (testicular volume less than 10 cc in 4) and a large testis subset (testicular volume 10 cc or greater in 6). Semen analysis parameters and serum testosterone were increased significantly after treatment in large testis subset.
CONCLUSION
Infertile men with HH initiate and maintain spermatogenesis with gonadotropin (hCG/hMG alone or combined) therapy, thus gonadotropin therapy is good choice in infertile men with HH.

Keyword

Hypogonadotropic hypogonadism; Gonadotropin; Fertility; Pregnancy outcome

MeSH Terms

Chorion
Female
Fertility
Follicle Stimulating Hormone
Gonadotropins
Humans
Hypogonadism
Infertility, Male
Male
Pregnancy
Pregnancy Outcome
Semen Analysis
Sperm Count
Spermatogenesis
Testis
Testosterone
Follicle Stimulating Hormone
Gonadotropins
Testosterone