Lab Anim Res.  2012 Sep;28(3):209-215. 10.5625/lar.2012.28.3.209.

Evaluating the effects of pentoxifylline administration on experimental pressure sores in rats by biomechanical examinations

Affiliations
  • 1Cell and Molecular Biology Research Center and Anatomy Department, Medical Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohbayat@sbmu.ac.ir
  • 2Physiotherapy Department, Medical Sciences faculty, Tarbiat Modrres University, Tehran, Iran.
  • 3Sciences Faculty, Islamic Azad University, Tehran, Iran.
  • 4Dental Faculty, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

This study used a biomechanical test to evaluate the effects of pentoxifylline administration on the wound healing process of an experimental pressure sore induced in rats. Under general anesthesia and sterile conditions, experimental pressure sores generated by no. 25 Halsted mosquito forceps were inflicted on 12 adult male rats. Pentoxifylline was injected intraperitoneally at a dose of 50 mg/kg daily from the day the pressure sore was generated, for a period of 20 days. At the end of 20 days, rats were sacrificed and skin samples extracted. Samples were biomechanically examined by a material testing instrument for maximum stress (N mm2), work up to maximum force (N), and elastic stiffness (N/mm). In the experimental group, maximum stress (2.05+/-0.15) and work up to maximum force (N/mm) (63.75+/-4.97) were significantly higher than the control group (1.3+/-0.27 and 43.3+/-14.96, P=0.002 and P=0.035, respectively). Pentoxifylline administration significantly accelerated the wound healing process in experimental rats with pressure sores, compared to that of the control group.

Keyword

Experimental model of pressure sore; rat; biomechanical test; pentoxifylline
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