- Is Tranexamic Acid an Effective Prevention in the Formation of Epidural Fibrosis? Histological Evaluation in the Rats
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Circi E, Atici Y, Baris A, Senel A, Leblebici C, Tekin SB, Ozturkmen Y
- KMID: 2545341
- J Korean Neurosurg Soc.
- 2023 Sep;66(5):503-510.
- doi: 10.3340/jkns.2022.0249
Objective : The present study aimed to determine the topical and systemic efficacy of tranexamic acid (TXA) on epidural fibrosis in a rat laminectomy model. Methods : Thirty-two 12-month-old adult Sprague-Dawley... -
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- Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/ PKA/CREB signaling pathway in the trigeminal ganglion in rats
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Zhai Q, Wang K, Zhang D, Chen J, Dong X, Pan Y
- KMID: 2544245
- Korean J Pain.
- 2023 Jul;36(3):335-346.
- doi: 10.3344/kjp.23039
Background: Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this... -
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- Nicotinamide Mononucleotide Adenylyl Transferase 2 Inhibition Aggravates Neurological Damage after Traumatic Brain Injury in a Rat Model
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Gu X, Ni H, Kan X, Chen C, Zhou Z, Ding Z, Li D, Liu B
- KMID: 2543531
- J Korean Neurosurg Soc.
- 2023 Jul;66(4):400-408.
- doi: 10.3340/jkns.2022.0115
Objective : Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a crucial factor for the survival of neuron. The role of NMNAT2 in damage following traumatic brain injury (TBI) remains unknown.... -
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- A Comparative Study of Dichloromethane and Ethyl Acetate Root Extracts of Celosia trigyna: Phytochemical and Wound Healing Effect Analyses
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Ofusori AE, Raharjo Y, Ofusori DA, Adekunle VO
- KMID: 2543854
- J Wound Manag Res.
- 2023 Jun;19(2):87-95.
- doi: 10.22467/jwmr.2023.02411
Background: Celosia species have been validated to possess antimicrobial, anti-inflammatory, and antioxidant potential. This study was thus designed to comparatively determine the effect of dichloromethane and ethyl acetate root extracts... -
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- Anti-osteoarthritis effect of Boswellia serrata gum resin extract in monosodium iodoacetate-induced osteoarthritic Sprague-Dawley rats
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Jung JI, Kim R, Kim EJ
- KMID: 2544281
- J Nutr Health.
- 2023 Jun;56(3):231-246.
- doi: 10.4163/jnh.2023.56.3.231
Purpose The aim of this study was to investigate the anti-osteoarthritic effect of the ethanol extract of Boswellia serrata gum resin (FJH-UBS) enriched with keto-β-boswellic acid and 3-O-acetyl-11-keto-β-boswellic acid compared to... -
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- Radioprotective role of amifostine on osteointegration of titanium implants in the tibia of rats
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Celep NA, Kara H, Erbaş E, Doğan E
- KMID: 2542985
- J Vet Sci.
- 2023 May;24(3):e35.
- doi: 10.4142/jvs.23023
Background: Titanium is the most widely used metal for bone integration, especially for cancer patients receiving ionizing radiation. This study aimed to investigate the amifostine administration that would reduce the... -
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- Calcium/calmodulin-dependent protein kinase II is involved in the transmission and regulation of nociception in naïve and morphine-tolerant rat nucleus accumbens
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Xi KW, Chen DD, Geng X, Bian Y, Wang MX, Bian H
- KMID: 2541025
- Korean J Pain.
- 2023 Apr;36(2):163-172.
- doi: 10.3344/kjp.22372
Background: Synaptic plasticity contributes to nociceptive signal transmission and modulation, with calcium/ calmodulin-dependent protein kinase II (CaMK II) playing a fundamental role in neural plasticity. This research was conducted to... -
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- Chitosan Nerve Grafts Incorporated with SKP-SC-EVs Induce Peripheral Nerve Regeneration
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Zhou X, Yu M, Chen D, Deng C, Zhang Q, Gu X, Ding F
- KMID: 2541495
- Tissue Eng Regen Med.
- 2023 Apr;20(2):309-322.
- doi: 10.1007/s13770-022-00517-6
BACKGROUND: Repair of long-distance peripheral nerve defects remains an important clinical problem. Nerve grafts incorporated with extracellular vesicles (EVs) from various cell types have been developed to bridge peripheral nerve... -
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- Evaluation of the effects of bupivacaine combined with sugammadex on the duration of the nociceptive blockade in sciatic nerve blocks: a controlled, double-blind animal study
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Tasargol O, Darbaz I, Ergene O, Zabitler F, Deniz A, Kose SG, Kose HC, Tulgar S
- KMID: 2541005
- Korean J Anesthesiol.
- 2023 Apr;76(2):152-159.
- doi: 10.4097/kja.22486
Background: Animal and other experimental studies have demonstrated increased block time and quality when α- and β-cyclodextrin drugs are combined with local anesthetics. However, to our knowledge, no study has... -
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- Silymarin attenuates escitalopram (cipralex) induced pancreatic injury in adult male albino rats: a biochemical, histological, and immunohistochemical approach
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Salama RM, Tayel SG
- KMID: 2540991
- Anat Cell Biol.
- 2023 Mar;56(1):122-136.
- doi: 10.5115/acb.22.204
Depression is a prevalent global problem since ages, predominately treated with SSRI. Cipralex, is an antidepressant of the SSRIs class used as a remedy for mood, depression and anxiety. Silymarin... -
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- Decreased Expression of Urethral Caveolin-1, -2, and -3 in the Rat Model of Overactive Bladder: Potential Mediator of Functional Interaction of Urethra and Urinary Bladder
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Cho HJ, Jiao HY, Kim SO
- KMID: 2540798
- Int Neurourol J.
- 2023 Mar;27(1):47-54.
- doi: 10.5213/inj.2244236.118
Purpose: To investigate the effect of detrusor overactivity (DO) on the urethral expression of caveolin (CAV)-1, -2, and -3 of urethra in an animal model of cyclophosphamide (CYP)-induced cystitis rat. Methods:... -
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- Effects of Mesenchymal Stem Cells Treatment on Radiation-Induced Proctitis in Rats
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Kim WH, Yoo JH, Yoo IK, Kwon CI, Hong SP
- KMID: 2539559
- Yonsei Med J.
- 2023 Mar;64(3):167-174.
- doi: 10.3349/ymj.2022.0342
Purpose: There are no effective treatment methods with which to control complications of radiation proctitis with fistula or recurrent bleeding following radiation treatment for prostate, cervical, or rectal cancer. Mesenchymal... -
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- Efficacy and Safety of Human Bone Marrow-Derived Mesenchymal Stem Cells according to Injection Route and Dose in a Chronic Kidney Disease Rat Model
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Chae HK, Suh N, Jang MJ, Kim YS, Kim BH, Aum J, Shin HC, You D, Hong B, Park HK, Kim CS
- KMID: 2539622
- Int J Stem Cells.
- 2023 Feb;16(1):66-77.
- doi: 10.15283/ijsc21146
Background and Objectives: We compared the efficacy and safety of human bone marrow-derived mesenchymal stem cells (hBMSC), delivered at different doses and via different injection routes in an animal model... -
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- Environmental measures and healthcare service utilization against laboratory animal allergy in Korean laboratory animal researchers
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Kang SY, Won HK, Park SY, Lee SM, Lee SP
- KMID: 2538967
- Allergy Asthma Respir Dis.
- 2023 Jan;11(1):18-25.
- doi: 10.4168/aard.2023.11.1.18
Purpose: This study aimed to evaluate the environmental measures and healthcare service utilization against laboratory animal allergy (LAA) in Korea. Methods: A total of 213 subjects who attended the 2018 Korean... -
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- Enhancing the Effect of Placental Extract on the Regeneration of Crush Injured Facial Nerve
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Lim GM, Cho GW, Ganesan CD, Choi JH, Ang MJ, Moon C, Jang CH
- KMID: 2537961
- Exp Neurobiol.
- 2022 Dec;31(6):419-430.
- doi: 10.5607/en22006
There is a scarcity of experimental studies on peripheral nerve regeneration using placental extract (PE). This study aimed to investigate the effects of topical PE application on recovery after crush... -
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- Morphological, ultrastructural, and biochemical changes induced by sodium fluoride in the tongue of adult male albino rat and the ameliorative effect of resveratrol
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El-Bestawy EM, Tolba AM, Rashad WA
- KMID: 2537468
- Anat Cell Biol.
- 2022 Dec;55(4):483-496.
- doi: 10.5115/acb.22.088
Little knowledge is available about the effects of fluoride exposure on the tongue. This study evaluated the effects of sodium fluoride (NaF) on the tongue ultrastructure and detected the ameliorative... -
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- Tissues toxicity attenuation by vitamin E on oxidative damage induced by diazinon
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Tahmasebi K, Jafari M, Heydari J, Asgari A, Salehi M, Khazaie S, Abedini MS
- KMID: 2539840
- Environ Anal Health Toxicol.
- 2022 Dec;37(4):e2022036.
- doi: 10.5620/eaht.2022036
Organophosphorus insecticides such as diazinon (DZN) are used worldwide in industry, veterinary practice, and agriculture. They may induce oxidative stress in different tissues. The use of antioxidants can protect tissues... -
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- Temporal Modulation of DNA Methylation and Gene Expression in Monolayer and 3D Spheroids of Dental Pulp Stem Cells during Osteogenic Differentiation: A Comparative Study
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Raik S, Thakur R, Rattan V, Kumar N, Pal A, Bhattacharyya S
- KMID: 2536457
- Tissue Eng Regen Med.
- 2022 Dec;19(6):1267-1282.
- doi: 10.1007/s13770-022-00485-x
BACKGROUND: Human mesenchymal stem cells are being used for various regenerative applications in past decades. This study chronicled a temporal profile of the transcriptional pattern and promoter methylation status of the... -
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- Delayed-Onset Perforating Phenomenon in a Patient with Sorafenib-Induced Psoriasiform Eruption
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Song CH, Song SY, Kim JE, Ro YS, Ko JY
- KMID: 2536330
- Korean J Dermatol.
- 2022 Nov;60(9):628-630.
Sorafenib is an inhibitor of receptor tyrosine kinases and the rat sarcoma/mitogen-activated protein kinase (RAS/MAPK) pathway that is approved for the treatment of patients with metastatic hepatocellular carcinoma (HCC) and... -
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- Enhancement of bioactivity and osseointegration in Ti-6Al-4V orthodontic mini-screws coated with calcium phosphate on the TiO 2 nanotube layer
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Byeon SM, Kim HJ, Lee MH, Bae TS
- KMID: 2536334
- Korean J Orthod.
- 2022 Nov;52(6):412-419.
- doi: 10.4041/kjod22.118
Objective: This study evaluated the effect of cyclic pre-calcification treatment on the improvement of bioactivity and osseointegration of Ti-6Al-4V miniscrews. Methods: The experimental groups were: an untreated group (UT), an... -
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