Korean J Radiol.  2004 Mar;5(1):19-24. 10.3348/kjr.2004.5.1.19.

Usefulness of Multidetector-row CT in the Evaluation of Reperfused Myocardial Infarction in a Rabbit Model

• Park JM
• Choe YH
• Chang S
• Sung YM
• Kang SS
• Kim MJ
• Han BK
• Choi SH

• KMID: 1066241
• DOI: http://doi.org/10.3348/kjr.2004.5.1.19

Abstract

OBJECTIVE
To evaluate the usefulness of multidetector-row computed tomography (CT) in the evaluation of reperfused myocardial infarction. MATERIALS AND METHODS: Eleven rabbits were subjected to 90-min occlusion of the left anterior descending coronary artery followed by reperfusion. Multidetector-row CT was performed 31 hours+/-21 after the procedure and preand post-contrast multiphase helical CT images were obtained up to 10 min after contrast injection. The animals were sacrificed after 30 days and histochemical staining of the resected specimens was perfomed with 2'3'5-triphenyl tetrazolium chloride (TTC). RESULTS: In all 11 cases, the areas of myocardial infarction demonstrated with TTC-staining were identified on the CT images and the lesions showed hypoenhancement on the early phases up to 62 sec and hyperenhancement on the delayed phases of 5 min and 10 min compared with normal myocardial enhancement. The percentage area of the lesion with respect to the left ventricle wall on CT was significantly correlated with that of the TTC-staining results (p < 0.001 for both early and delayed phase CT) according to the generalized linear model analysis. The areas showing hypoenhancement on early CT were significantly smaller than those with hyperenhancement on delayed CT (p < 0.0001). CONCLUSION: Multidetector-row CT may be useful in the detection and sizing of reperfused myocardial infarction.

Keyword

Animals; Computed tomography (CT), multidetector-row; Computed tomography (CT), helical technology; Myocardium, infarction; Myocardium, CT; Heart, CT

MeSH Terms

Animals
Feasibility Studies
Models, Animal
Myocardial Infarction/*radiography
Myocardial Reperfusion Injury/*radiography
Rabbits
Reproducibility of Results
Support, Non-U.S. Gov't
Tomography, Spiral Computed
*Tomography, X-Ray Computed/methods

Figure

• 

  Fig. 1 Extensive myocardial infarction. Early-phase CT obtained at 27 sec following administration of contrast material (A) showed hypoenhancement (arrows) and 10-min-delayed image (B) showed hyperenhancement (arrows) in the anterior wall compared with normal myocardium. 2'3'5-triphenyl tetrazolium chloride-stained specimen obtained at four weeks after coronary artery occlusion and reperfusion (C) shows damaged myocardium (arrows) as a 2'3'5-triphenyl tetrazolium chloride-unstained area with wall thinning.

• 

  Fig. 2 Line graph of pooled data from all 11 rabbits shows enhancement patterns of normal myocardium and infarct myocardium on CT images. Infarct areas showed hypoenhancement at early phases and hyperenhancement at late phases compared with normal myocardium.

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