- Prognostic Implication of Telomerase Activity in Patients with Brain Tumors
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Kim CH, Cheong JH, Bak KH, Kim JM, Oh SJ
- KMID: 2157795
- J Korean Med Sci.
- 2006 Feb;21(1):126-130.
- doi: 10.3346/jkms.2006.21.1.126
Telomerase adds telomeric repeats to the ends of telomeres to compensate for their progressive loss. A favorable prognosis is associated with low or no telomerase in some tumors. The authors... -
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- The Spectrum of NF1 Mutations in Korean Patients with Neurofibromatosis Type 1
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Jeong SY, Park SJ, Kim HJ
- KMID: 2157792
- J Korean Med Sci.
- 2006 Feb;21(1):107-112.
- doi: 10.3346/jkms.2006.21.1.107
Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders in humans. NF1 is caused by mutations in the NF1 gene which consists of 57 exons and... -
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- Assessment of Fluid Shifts of Body Compartments using Both Bioimpedance Analysis and Blood Volume Monitoring
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Yu SJ, Kim DH, Oh DJ, Yu SH, Kang ET
- KMID: 2157786
- J Korean Med Sci.
- 2006 Feb;21(1):75-80.
- doi: 10.3346/jkms.2006.21.1.75
Fluid shifts are commonplace in chronic hemodialysis patients during the intra- and interdialytic periods. In this study, we evaluated fluid shifts of body compartments using both bioimpedance spectroscopy and blood... -
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- Impact of Circulating TGF-beta and IL-10 on T Cell Cytokines in Patients with Asthma and Tuberculosis
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Jang AS, Park SW, Ahn MH, Park JS, Kim DJ, Lee JH, Park CS
- KMID: 2157778
- J Korean Med Sci.
- 2006 Feb;21(1):30-34.
- doi: 10.3346/jkms.2006.21.1.30
Regulatory T cells, which stimulate or inhibit the effector functions of distinct T cell subsets, are critical in the control of the immune response. We investigated the effect of TGF-beta... -
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- Aprotinin Attenuates the Elevation of Pulmonary Vascular Resistance After Cardiopulmonary Bypass
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Yun TJ, Rho JR
- KMID: 2157777
- J Korean Med Sci.
- 2006 Feb;21(1):25-29.
- doi: 10.3346/jkms.2006.21.1.25
Pulmonary vascular resistance (PVR) is generally believed to be elevated after cardiopulmonary bypass (CPB) due to whole body inflammation. Aprotinin has an antiinflammatory action, and it was hypothesized that aprotinin... -
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- Naltrexone influences protein kinase C epsilon and integrin alpha7 activity in SH-SY5Y neuroblastoma cells
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Oh DY, Jung KH, Yang BH, Lee JS, Choi IG, Chai YG
- KMID: 1105282
- Exp Mol Med.
- 2006 Feb;38(1):100-106.
Alcohol influences the neuroadaptation of brain cells where receptors and enzymes like protein kinase C (PKC) exist. Naltrexone acts on opioid receptors. However, other mechanisms of action remain unknown. We... -
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- Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor
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Kim J, Choi WS, Kim HJ, Kwon B
- KMID: 1105281
- Exp Mol Med.
- 2006 Feb;38(1):94-99.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive... -
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- Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
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Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG
- KMID: 1105280
- Exp Mol Med.
- 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,... -
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- Impaired responses of leukemic dendritic cells derived from a human myeloid cell line to LPS stimulation
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Kim KD, Choi SC, Noh YW, Kim JW, Paik SG, Yang Y, Kim KI, Lim JS
- KMID: 1105279
- Exp Mol Med.
- 2006 Feb;38(1):72-84.
Several myeloid leukemia-derived cells have been reported to possess the ability to differentiate into dendritic cells (DC). MUTZ-3, a myeloid leukemia cell line, responds to GM-CSF, IL-4 and TNF-alpha, and... -
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- Shear stress stimulates phosphorylation of protein kinase A substrate proteins including endothelial nitric oxide synthase in endothelial cells
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Boo YC
- KMID: 1105278
- Exp Mol Med.
- 2006 Feb;38(1):63-71.
Fluid shear stress plays a critical role in vascular health and disease. While protein kinase A (PKA) has been implicated in shear-stimulated signaling events in endothelial cells, it remains unclear... -
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- Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
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Ahn BH, Min G, Bae YS, Bae YS, Min DS
- KMID: 1105277
- Exp Mol Med.
- 2006 Feb;38(1):55-62.
Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and... -
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- Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus
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Lee KJ, Kim SJ, Kim SW, Choi SH, Shin YC, Park SH, Moon BH, Cho E, Lee MS, Choi SH, Chun BG, Shin KH
- KMID: 1105276
- Exp Mol Med.
- 2006 Feb;38(1):44-54.
New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not... -
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- The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
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Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H
- KMID: 1105275
- Exp Mol Med.
- 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation... -
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- Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines
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Lee KH, Choi EY, Kim MK, Hyun MS, Jang BI, Kim TN, Kim SW, Song SK, Kim JH, Kim JR
- KMID: 1105274
- Exp Mol Med.
- 2006 Feb;38(1):27-35.
The regulatory mechanisms for the proliferation and the particular invasive phenotypes of stomach cancers are not still fully understood. Up-regulations of hepatocytes growth factor (HGF), its receptor (c-Met), and urokinase-type... -
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- Structure-activity relationships of anti-HIV-1 peptides with disulfide linkage between D- and L-cysteine at positions i and i+3, respectively, derived from HIV-1 gp41 C-peptide
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Lee MK, Kim HK, Lee TY, Hahm KS, Kim KL
- KMID: 1105273
- Exp Mol Med.
- 2006 Feb;38(1):18-26.
The constrained alpha-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an alpha-helical structure are located close together, therefore D-Cys (dC) and... -
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- Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death
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Choi YK, Kim TK, Kim CJ, Lee JS, Oh SY, Joo HS, Foster DN, Hong KC, You S, Kim H
- KMID: 1105272
- Exp Mol Med.
- 2006 Feb;38(1):11-17.
The mitochondrial pathway of swine influenza virus (SIV)-induced apoptosis was investigated using porcine kidney (PK-15) cells, swine testicle (ST) cells, and HeLa cervical carcinoma cells which are known not to... -
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- GSTM1, GSTT1 and GSTP1 Polymorphisms in the Korean Population
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Cho HJ, Lee SY, Ki CS, Kim JW
- KMID: 2157771
- J Korean Med Sci.
- 2005 Dec;20(6):1089-1092.
- doi: 10.3346/jkms.2005.20.6.1089
The isoenzymes of the glutathione s transferase (GST) family play a vital role in phase II of biotransformation of many substances. Using a multiplex polymerase chain reaction and a direct... -
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- An Infantile Case of Sturge-Weber Syndrome in Association with Klippel-Trenaunay-Weber Syndrome and Phakomatosis Pigmentovascularis
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Lee CW, Choi DY, Oh YG, Yoon HS, Kim JD
- KMID: 2157769
- J Korean Med Sci.
- 2005 Dec;20(6):1082-1084.
- doi: 10.3346/jkms.2005.20.6.1082
Sturge-Weber syndrome can be associated with facial port-wine stains and intracranial calcification, and concurrent Klippel-Trenaunay-Weber syndrome has been reported. Klippel-Trenaunay-Weber syndrome is a rare congenital mesodermal phakomatosis characterized by cutaneous... -
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- Two Novel Mutations in the Aquaporin 2 Gene in a Girl with Congenital Nephrogenic Diabetes Insipidus
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Cheong HI, Cho SJ, Zheng SH, Cho HY, Ha IS, Choi Y
- KMID: 2157767
- J Korean Med Sci.
- 2005 Dec;20(6):1076-1078.
- doi: 10.3346/jkms.2005.20.6.1076
Congenital nephrogenic diabetes insipidus (CNDI) is a rare inherited disorder characterized by insensitivity of the kidney to the antidiuretic effect of vasopressin. There are three inheritance patterns of CNDI: the... -
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- Intraabdominal Cryptococcal Lymphadenitis in a Patient with Systemic Lupus Erythematosus
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Kim SH, Kim SD, Kim HR, Yoon CH, Lee SH, Kim HY, Park SH
- KMID: 2157762
- J Korean Med Sci.
- 2005 Dec;20(6):1059-1061.
- doi: 10.3346/jkms.2005.20.6.1059
Cryptococcal infection is a rare, yet well recognized complication of systemic lupus erythematosus (SLE). We present a case of mesenteric and retroperitoneal cryptococcal lymphadenitis resulting in the obstruction of the... -
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