- Mechanism of Wenshen Xuanbi Decoction in the treatment of osteoarthritis based on network pharmacology and experimental verification
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You H, Song S, Liu D, Ren T, Yin SJ, Wu P, Mao J
- KMID: 2550289
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):59-72.
- doi: 10.4196/kjpp.2024.28.1.59
To investigate the mechanism of Wenshen Xuanbi Decoction (WSXB) in treating osteoarthritis (OA) via network pharmacology, bioinformatics analysis, and experimental verification. The active components and prediction targets of WSXB were... -
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- Store-operated calcium entry in the satellite glial cells of rat sympathetic ganglia
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Kim S, Kang SJ, Nguyen HS, Jeong SW
- KMID: 2550292
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):93-103.
- doi: 10.4196/kjpp.2024.28.1.93
Satellite glial cells (SGCs), a major type of glial cell in the autonomic ganglia, closely envelop the cell body and even the synaptic regions of a single neuron with a... -
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- Naringenin modulates GABA mediated response in a sexdependent manner in substantia gelatinosa neurons of trigeminal subnucleus caudalis in immature mice
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Park SA, Nguyen TTP, Park SJ, Han SK
- KMID: 2550290
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):73-81.
- doi: 10.4196/kjpp.2024.28.1.73
The substantia gelatinosa (SG) within the trigeminal subnucleus caudalis (Vc) is recognized as a pivotal site of integrating and modulating afferent fibers carrying orofacial nociceptive information. Although naringenin (4',5,7-thrihydroxyflavanone), a... -
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- Inhibition of Wnt/ββ-catenin signaling by monensin in cervical cancer
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Fu B, Fang L, Wang R, Zhang X
- KMID: 2550276
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):21-30.
- doi: 10.4196/kjpp.2024.28.1.21
The challenging clinical outcomes associated with advanced cervical cancer underscore the need for a novel therapeutic approach. Monensin, a polyether antibiotic, has recently emerged as a promising candidate with anti-cancer... -
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- Differential expression of the enzymes regulating myosin light chain phosphorylation are responsible for the slower relaxation of pulmonary artery than mesenteric artery in rats
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Oh SB, Cho S, Kim HJ, Kim SJ
- KMID: 2550288
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):49-57.
- doi: 10.4196/kjpp.2024.28.1.49
While arterial tone is generally determined by the phosphorylation of Ser19 in myosin light chain (p-MLC2), Thr18 /Ser19 diphosphorylation of MLC2 (ppMLC2) has been suggested to hinder the relaxation of... -
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- Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis
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Jung SR, Lee JH, Ryu H, Gao Y, Lee J
- KMID: 2550286
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):31-38.
- doi: 10.4196/kjpp.2024.28.1.31
As in type 1 diabetes, the loss of pancreatic β-cells leads to insulin deficiency and the subsequent development of hyperglycemia. Exercise has been proposed as a viable remedy for hyperglycemia.... -
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- Carvacrol improves blood lipid and glucose in rats with type 2 diabetes mellitus by regulating short-chain fatty acids and the GPR41/43 pathway
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Sun Y, Qu H, Niu X, Li T, Wang L, Peng H
- KMID: 2550274
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):1-10.
- doi: 10.4196/kjpp.2024.28.1.1
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and dyslipidemia. Carvacrol (CAR) has demonstrated the potential to mitigate dyslipidemia. This study aims to investigate whether CAR can modulate blood... -
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- ACY-241, a histone deacetylase 6 inhibitor, suppresses the epithelial–mesenchymal transition in lung cancer cells by downregulating hypoxia-inducible factor-1 alpha
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Park SJ, Lee N, Jeong CH
- KMID: 2550291
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):83-91.
- doi: 10.4196/kjpp.2024.28.1.83
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor activated under hypoxic conditions, and it plays a crucial role in cellular stress regulation. While HIF-1α activity is essential in normal tissues, its... -
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- Wogonin attenuates vascular remodeling by inhibiting smooth muscle cell proliferation and migration in hypertensive rat
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Yang Y, Huang S, Wang J, Nie X, Huang L, Li T
- KMID: 2550287
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):39-48.
- doi: 10.4196/kjpp.2024.28.1.39
Wogonin, extracted from the roots of Scutellaria baicalensis Georgi, has been shown to suppress collagen deposition in spontaneously hypertensive rats (SHRs). This study was performed to investigate the role and... -
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- Aurantio-obtusin exerts an anti-inflammatory effect on acute kidney injury by inhibiting NF-κκB pathway
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Xiang H, Zhang Y, Wu Y, Xu Y, Hong Y
- KMID: 2550275
- Korean J Physiol Pharmacol.
- 2024 Jan;28(1):11-19.
- doi: 10.4196/kjpp.2024.28.1.11
Acute kidney injury (AKI) is one of the major complications of sepsis. Aurantio-obtusin (AO) is an anthraquinone compound with antioxidant and antiinflammatory activities. This study was developed to concentrate on the... -
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