- Negative self-regulation of transient receptor potential canonical 4 by the specific interaction with phospholipase C-δ1
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Ko J, Kim J, Myeong J, Kwak M, So I
- KMID: 2539573
- Korean J Physiol Pharmacol.
- 2023 Mar;27(2):187-196.
- doi: 10.4196/kjpp.2023.27.2.187
Transient receptor potential canonical (TRPC) channels are non-selective calcium-permeable cation channels. It is suggested that TRPC4β is regulated by phospholipase C (PLC) signaling and is especially maintained by phosphatidylinositol 4,5-bisphosphate... -
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- KLF9 deficiency protects the heart from inflammatory injury triggered by myocardial infarction
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Chang Z, Li H
- KMID: 2539572
- Korean J Physiol Pharmacol.
- 2023 Mar;27(2):177-185.
- doi: 10.4196/kjpp.2023.27.2.177
The excessive inflammatory response induced by myocardial infarction exacerbates heart injury and leads to the development of heart failure. Recent studies have confirmed the involvement of multiple transcription factors in... -
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- Hsa_circ_0129047 sponges miR-665 to attenuate lung adenocarcinoma progression by upregulating protein tyrosine phosphatase receptor type B
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Xia X, Fan J, Fan Z
- KMID: 2539568
- Korean J Physiol Pharmacol.
- 2023 Mar;27(2):131-141.
- doi: 10.4196/kjpp.2023.27.2.131
Compelling evidence has demonstrated the critical role of circular RNAs (circRNAs) during lung adenocarcinoma (LUAD) progression. Herein, we explored a novel circRNA, circ_0129047, and detailed its mechanism of action. The... -
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- Rehmannioside D mitigates disease progression in rats with experimental-induced diminished ovarian reserve via Forkhead Box O1/KLOTHO axis
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Liang Y, Wang H, Chen J, Chen L, Chen X
- KMID: 2539571
- Korean J Physiol Pharmacol.
- 2023 Mar;27(2):167-176.
- doi: 10.4196/kjpp.2023.27.2.167
This study aims to explore the impact of Rehmannioside D (RD) on ovarian functions of rats with diminished ovarian reserve (DOR) and its underlying mechanisms of action. A single injection... -
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- The expression of Rab5 and its effect on invasion, migration and exosome secretion in triple negative breast cancer
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Qiao L, Dong C, Zhang J, Sun G
- KMID: 2539570
- Korean J Physiol Pharmacol.
- 2023 Mar;27(2):157-165.
- doi: 10.4196/kjpp.2023.27.2.157
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and current therapeutic strategies are limited in their effectiveness. The expressions of Rab5 and the M2 tumor-associated macrophage marker... -
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- Resveratrol pretreatment alleviates NLRP3 inflammasomemediated cardiomyocyte pyroptosis by targeting TLR4/MyD88/ NF-κB signaling cascade in coronary microembolization-induced myocardial damage
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Luo CJ, Li T, Li HL, Zhou Y, Li L
- KMID: 2539569
- Korean J Physiol Pharmacol.
- 2023 Mar;27(2):143-155.
- doi: 10.4196/kjpp.2023.27.2.143
Percutaneous coronary intervention and acute coronary syndrome are both closely tied to the frequently occurring complication of coronary microembolization (CME). Resveratrol (RES) has been shown to have a substantial cardioprotective... -
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