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Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells

Yun HH, Baek JY, Seo G, Kim YS, Ko JH, Lee JH

The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1)...
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Angiotensin-(1-9) ameliorates pulmonary arterial hypertension via angiotensin type II receptor

Cha SA, Park BM, Kim SH

Angiotensin-(1-9) [Ang-(1-9)], generated from Ang I by Ang II converting enzyme 2, has been reported to have protective effects on cardiac and vascular remodeling. However, there is no report about...
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α-Isocubebene modulates vascular tone by inhibiting myosin light chain phosphorylation in murine thoracic aorta

Ye BH, Kim EJ, Baek SE, Choi YW, Park SY, Kim CD

α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined....
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Concurrent treatment with ursolic acid and low-intensity treadmill exercise improves muscle atrophy and related outcomes in rats

Kim JC, Kang YS, Noh EB, Seo BW, Seo DY, Park GD, Kim SH

The objective of this study was to analyze the concurrent treatment effects of ursolic acid (UA) and low-intensity treadmill exercise and to confirm the effectiveness of UA as an exercise...
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The effect of µ-opioid receptor activation on GABAergic neurons in the spinal dorsal horn

Kim YR, Shim HG, Kim CE, Kim SJ

The superficial dorsal horn of the spinal cord plays an important role in pain transmission and opioid activity. Several studies have demonstrated that opioids modulate pain transmission, and the activation...
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Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

Wang Y, Huang M, Yang X, Yang Z, Li L, Mei J

Pre-eclampsia (PE) is a pregnancy disorder that is characterised by severe hypertension and increased risks of foetal and maternal mortality. The aetiology of PE not completely understood; however, maternal nutrition...
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Lipidomic analysis of plasma lipids composition changes in septic mice

Ahn WG, Jung JS, Song DK

A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine...
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Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus

Muñoz-Pérez VM, Ortiz MI, Ponce-Monter HA, Monter-Pérez V, Barragán-Ramírez G

The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used...
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Adenine attenuates lipopolysaccharide-induced inflammatory reactions

Silwal P, Lim K, Heo JY, Park JI, Namgung U, Park SK

A nucleobase adenine is a fundamental component of nucleic acids and adenine nucleotides. Various biological roles of adenine have been discovered. It is not produced from degradation of adenine nucleotides...
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Isoliquiritigenin attenuates spinal tuberculosis through inhibiting immune response in a New Zealand white rabbit model

Wang W, Yang B, Cui Y, Zhan Y

Spinal tuberculosis (ST) is the tuberculosis caused by Mycobacterium tuberculosis (Mtb) infections in spinal curds. Isoliquiritigenin 4,2′,4′-trihydroxychalcone, ISL) is an anti-inflammatory flavonoid derived from licorice (Glycyrrhiza uralensis), a Chinese traditional...
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Role of peripheral vestibular receptors in the control of blood pressure following hypotension

Jin GS, Li XL, Jin YZ, Kim MS, Park BR

Hypotension is one of the potential causes of dizziness. In this review, we summarize the studies published in recent years about the electrophysiological and pharmacological mechanisms of hypotension-induced dizziness and...
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