Korean J Physiol Pharmacol.  2018 Jul;22(4):363-368. 10.4196/kjpp.2018.22.4.363.

Role of peripheral vestibular receptors in the control of blood pressure following hypotension

  • 1Department of Cerebral Surgery, Yanbian University College of Clinical Medicine, Yanji 133000, China.
  • 2Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanji 133002, China. lixl1972@ybu.edu.cn
  • 3Department of Physiology, Wonkwang University School of Medicine and Brain Science Institute at Wonkwang University, Iksan 54538, Korea. byungp@wku.ac.kr


Hypotension is one of the potential causes of dizziness. In this review, we summarize the studies published in recent years about the electrophysiological and pharmacological mechanisms of hypotension-induced dizziness and the role of the vestibular system in the control of blood pressure in response to hypotension. It is postulated that ischemic excitation of the peripheral vestibular hair cells as a result of a reduction in blood flow to the inner ear following hypotension leads to excitation of the central vestibular nuclei, which in turn may produce dizziness after hypotension. In addition, excitation of the vestibular nuclei following hypotension elicits the vestibulosympathetic reflex, and the reflex then regulates blood pressure by a dual-control (neurogenic and humoral control) mechanism. In fact, recent studies have shown that peripheral vestibular receptors play a role in the control of blood pressure through neural reflex pathways. This review illustrates the dual-control mechanism of peripheral vestibular receptors in the regulation of blood pressure following hypotension.


Dizziness; Epinephrine; Glutamate; Hypotension; Vestibulosympathetic reflex
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