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Myometrial relaxation of mice via expression of two pore domain acid sensitive K⁺ (TASK-2) channels

Kyeong KS, Hong SH, Kim YC, Cho W, Myung SC, Lee MY, You RY, Kim CH, Kwon SY, Suzuki H, Park YJ, Jeong EH, Kim HS, Kim H, Lim SW, Xu WX, Lee SJ, Ji IW

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):547-556.
  • doi: 10.4196/kjpp.2016.20.5.547
Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K⁺ channels (TASK-2) might be...
Nafamostat mesilate promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway

Choi S, Kwon HJ, Song HJ, Choi SW, Nagar H, Piao S, Jung SB, Jeon BH, Kim DW, Kim CS

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):539-545.
  • doi: 10.4196/kjpp.2016.20.5.539
Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has anticoagulant and anti-inflammatory properties. The intracellular mediator and external anti-inflammatory external signal in the vascular wall have been reported to protect...
Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway

Ha JM, Jin SY, Lee HS, Shin HK, Lee DH, Song SH, Kim CD, Bae SS

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):533-538.
  • doi: 10.4196/kjpp.2016.20.5.533
Angiogenesis plays an essential role in embryo development, tissue repair, inflammatory diseases, and tumor growth. In the present study, we showed that endothelial nitric oxide synthase (eNOS) regulates retinal angiogenesis....
DAMGO modulates two-pore domain K⁺ channels in the substantia gelatinosa neurons of rat spinal cord

Cho PS, Lee HK, Lee SH, Im JZ, Jung SJ

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):525-531.
  • doi: 10.4196/kjpp.2016.20.5.525
The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying K⁺...
Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion

Kim MY, Cho JY

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):515-523.
  • doi: 10.4196/kjpp.2016.20.5.515
Adhesion events of monocytes represent an important step in inflammatory responses induced by chemokines. The β1-integrin CD29 is a major adhesion molecule regulating leukocyte migration and extravasation. Although several adhesion...
Spatial reproducibility of complex fractionated atrial electrogram depending on the direction and configuration of bipolar electrodes: an in-silico modeling study

Song JS, Lee YS, Hwang M, Lee JK, Li C, Joung B, Lee MH, Shim EB, Pak HN

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):507-514.
  • doi: 10.4196/kjpp.2016.20.5.507
Although 3D-complex fractionated atrial electrogram (CFAE) mapping is useful in radiofrequency catheter ablation for persistent atrial fibrillation (AF), the directions and configuration of the bipolar electrodes may affect the electrogram....
Seasonal acclimation in sudomotor function evaluated by QSART in healthy humans

Shin YO, Lee JB, Kim JH

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):499-505.
  • doi: 10.4196/kjpp.2016.20.5.499
The quantitative sudomotor axon reflex testing (QSART) is a classic test of routine postganglionic sudomotor function. We investigated sudomotor function by QSART after summer (July 2012) and winter (January 2013)...
p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells

Shrestha M, Park PH

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):487-498.
  • doi: 10.4196/kjpp.2016.20.5.487
Leptin, an adipokine predominantly produced from adipose tissue, is well known to induce tumor growth. However, underlying molecular mechanisms are not established yet. While p53 has long been well recognized...
Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats

Lee E, Song MJ, Lee HA, Kang SH, Kim M, Yang EK, Lee DY, Ro S, Cho JM, Kim I

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):477-485.
  • doi: 10.4196/kjpp.2016.20.5.477
CG200745 is a novel inhibitor of histone deacetylases (HDACs), initially developed for treatment of various hematological and solid cancers. Because it is water-soluble, it can be administered orally. We hypothesized...
Effect of pertussis toxin pretreated centrally on blood glucose level induced by stress

Suh HW, Sim YB, Park SH, Sharma N, Im HJ, Hong JS

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):467-476.
  • doi: 10.4196/kjpp.2016.20.5.467
In the present study, we examined the effect of pertussis toxin (PTX) administered centrally in a variety of stress-induced blood glucose level. Mice were exposed to stress after the pretreatment...
Lnk is an important modulator of insulin-like growth factor-1/Akt/peroxisome proliferator-activated receptor-gamma axis during adipogenesis of mesenchymal stem cells

Lee JH, Lee SH, Lee HS, Ji ST, Jung SY, Kim JH, Bae SS, Kwon SM

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):459-466.
  • doi: 10.4196/kjpp.2016.20.5.459
Adipogenic differentiation of mesenchymal stem cells (MSCs) is critical for metabolic homeostasis and nutrient signaling during development. However, limited information is available on the pivotal modulators of adipogenic differentiation of...
N-acetyl-L-cysteine and cysteine increase intracellular calcium concentration in human neutrophils

Hasan MA, Ahn WG, Song DK

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):449-457.
  • doi: 10.4196/kjpp.2016.20.5.449
N-acetyl-L-cysteine (NAC) and cysteine have been implicated in a number of human neutrophils' functional responses. However, though Ca²⁺ signaling is one of the key signalings contributing to the functional responses...
Dexmedetomidine inhibits vasoconstriction via activation of endothelial nitric oxide synthase

Nong L, Ma J, Zhang G, Deng C, Mao S, Li H, Cui J

  • Korean J Physiol Pharmacol.
  • 2016 Sep;20(5):441-447.
  • doi: 10.4196/kjpp.2016.20.5.441
Despite the complex vascular effects of dexmedetomidine (DEX), its actions on human pulmonary resistance arteries remain unknown. The present study tested the hypothesis that DEX inhibits vascular tension in human...

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