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10 results

Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling

Lee HK, Seo IA, Lee SH, Seo SY, Kim KS, Park HT

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):281-286.
  • doi: 10.4196/kjpp.2008.12.5.281
Although the interaction between gp130 and the ErbB family has frequently been shown in cancer cells, the mechanism of this interaction remains unclear and controversial. In the present study, we...
Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain

Kang YJ, Park MK, Lee HS, Choi HC, Lee KY, Kim HJ, Seo HG, Lee JH, Chang KC

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):275-280.
  • doi: 10.4196/kjpp.2008.12.5.275
A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes...
Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes

Youm JB, Leem CH, Zhang YH, Kim N, Han J, Earm YE

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):267-274.
  • doi: 10.4196/kjpp.2008.12.5.267
Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied...
PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine

Kang TM

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):259-265.
  • doi: 10.4196/kjpp.2008.12.5.259
[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting...
Effects of Somatostatin on the Responses of Rostrally Projecting Spinal Dorsal Horn Neurons to Noxious Stimuli in Cats

Jung SJ, Jo SH, Lee S, Oh E, Kim MS, Nam WD, Oh SB

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):253-258.
  • doi: 10.4196/kjpp.2008.12.5.253
Somatostatin (SOM) is a widely distributed peptide in the central nervous system and exerts a variety of hormonal and neural actions. Although SOM is assumed to play an important role...
Single-Channel Recording of TASK-3-like K+ Channel and Up- Regulation of TASK-3 mRNA Expression after Spinal Cord Injury in Rat Dorsal Root Ganglion Neurons

Jang I, La JH, Kim GT, Lee JS, Kim EJ, Lee ES, Kim SJ, Seo JM, Ahn SH, Park JY, Hong SG, Kang D, Han J

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):245-251.
  • doi: 10.4196/kjpp.2008.12.5.245
Single-channel recordings of TASK-1 and TASK-3, members of two-pore domain K+ channel family, have not yet been reported in dorsal root ganglion (DRG) neurons, even though their mRNA and activity...
Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats

Cho CH, Shin HK

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):237-243.
  • doi: 10.4196/kjpp.2008.12.5.237
Intraplantar injection of melittin has been known to induce sustained decrease of mechanical threshold and increase of spontaneous flinchings. The present study was undertaken to investigate how the melittin-induced nociceptive...
Heparin Attenuates the Expression of TNF alpha-induced Cerebral Endothelial Cell Adhesion Molecule

Lee JH, Kim CH, Seo GH, Lee J, Kim JH, Kim DG, Ahn YS

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):231-236.
  • doi: 10.4196/kjpp.2008.12.5.231
Heparin is a well-known anticoagulant widely used in various clinical settings. Interestingly, recent studies have indicated that heparin also has anti-inflammatory effects on neuroinflammation-related diseases, such as Alzheimer's disease and...
Netrin-1 Specifically Enhances Cell Spreading on Fibronectin in Human Glioblastoma Cells

Lee HK, Seo IA, Shin YK, Lee SH, Seo SY, Suh DJ, Park HT

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):225-230.
  • doi: 10.4196/kjpp.2008.12.5.225
Netrins are secreted molecules and involved in axon guidance, cell migration and tumor development. Recent studies revealed that netrins perform novel functions in such processes as epithelial development and angiogenesis...
Role of Glucocorticoids in Fasting-induced Changes in Hypothalamic and Pituitary Components of the Growth Hormone (GH)-axis

Kim E, Seo S, Chung H, Park S

  • Korean J Physiol Pharmacol.
  • 2008 Oct;12(5):217-223.
  • doi: 10.4196/kjpp.2008.12.5.217
To directly test if elevated glucocorticoids are required for fasting-induced regulation of growth hormone (GH)-releasing hormone (GHRH), GHRH receptors (GHRH-R) and ghrelin receptors (GHS-R) expression, male rats were bilaterally adrenalectomized...

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