- Aging-Related Correlation between Serum Sirtuin 1 Activities and Basal Metabolic Rate in Women, but not in Men
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Lee HJ, Yang SJ
- KMID: 2377798
- Clin Nutr Res.
- 2017 Jan;6(1):18-26.
- doi: 10.7762/cnr.2017.6.1.18
Sirtuin (SIRT) is a main regulator of metabolism and lifespan, and its importance has been implicated in the prevention against aging-related diseases. The purpose of this study was to identify... -
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- BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers
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Semmler L, Reiter-Brennan C, Klein A
- KMID: 2441847
- J Breast Cancer.
- 2019 Mar;22(1):1-14.
- doi: 10.4048/jbc.2019.22.e6
Since the first cloning of BRCA1 in 1994, many of its cellular interactions have been elucidated. However, its highly specific role in tumorigenesis in the breast tissue—carriers of BRCA1 mutations... -
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- Involvement of miR-Let7A in inflammatory response and cell survival/apoptosis regulated by resveratrol in THP-1 macrophage
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Song J, Jun M, Ahn MR, Kim OY
- KMID: 2390139
- Nutr Res Pract.
- 2016 Aug;10(4):377-384.
- doi: 10.4162/nrp.2016.10.4.377
BACKGROUND/OBJECTIVES: Resveratrol, a natural polyphenol, has multiple functions in cellular responses including apoptosis, survival, and differentiation. It also participates in the regulation of inflammatory response and oxidative stress. MicroRNA-Let-7A (miR-Let7A),... -
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- Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
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Kim KE, Kim H, Heo RW, Shin HJ, Yi CO, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS
- KMID: 2285590
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):451-460.
- doi: 10.4196/kjpp.2015.19.5.451
Sirtuin 1 (SIRT1) is a mammalian NAD+-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and... -
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- Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells
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Bae EH, Joo SY, Ma SK, Lee J, Kim SW
- KMID: 2285594
- Korean J Physiol Pharmacol.
- 2016 May;20(3):229-236.
- doi: 10.4196/kjpp.2016.20.3.229
Resveratrol (RSV) may provide numerous protective eff ects against chronic inflammatory diseases. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress, and aldehyde products... -
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- Age-related Changes in the Sirtuin1-NFE2-related Factor 2 Signaling System in the Kidney
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Bae MN, Choi MS, Eum SH, Kim EN, Lim JH, Kim MY, Ban TH, Jang IA, Yoon HE, Park CW, Chang YS, Choi BS
- KMID: 2376944
- Korean J Med.
- 2017 Feb;92(1):53-61.
- doi: 10.3904/kjm.2017.92.1.53
BACKGROUND/AIMS: Renal aging-related changes are characterized by oxidative stress. SIRT1 regulates cellular conditions by activating Nrf2. The present study investigated the processes of renal changes by antioxidant enzymes and the... -
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- Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
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Lee HJ, Yang SJ
- KMID: 2434070
- Nutr Res Pract.
- 2019 Feb;13(1):3-10.
- doi: 10.4162/nrp.2019.13.1.3
BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents... -
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- Effects of dietary leucine supplementation on the hepatic mitochondrial biogenesis and energy metabolism in normal birth weight and intrauterine growth-retarded weanling piglets
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Su W, Xu W, Zhang H, Ying Z, Zhou L, Zhang L, Wang T
- KMID: 2412024
- Nutr Res Pract.
- 2017 Apr;11(2):121-129.
- doi: 10.4162/nrp.2017.11.2.121
BACKGROUND/OBJECTIVES: The study was conducted to evaluate the effects of dietary leucine supplementation on mitochondrial biogenesis and energy metabolism in the liver of normal birth weight (NBW) and intrauterine growth-retarded... -
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- SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
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Jung W, Hong KD, Jung WY, Lee E, Shin BK, Kim HK, Kim A, Kim BH
- KMID: 2277409
- Korean J Pathol.
- 2013 Aug;47(4):332-339.
BACKGROUND: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by... -
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