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12 results

Anti-Helicobacter pylori Compounds from Polygonum cuspidatum

Khalil AA, Park WS, Kim HJ, Akter KM, Ahn MJ

  • Nat Prod Sci.
  • 2016 Sep;22(3):220-224.
  • doi: 10.20307/nps.2016.22.3.220
Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20,...
New Production of Antibacterial Polycyclic Quinazoline Alkaloid, Thielaviazoline, from Anthranilic Acid by the Marine-Mudflat-Derived Fungus Thielavia sp.

Leutou AS, Yun K, Son BW

  • Nat Prod Sci.
  • 2016 Sep;22(3):216-219.
  • doi: 10.20307/nps.2016.22.3.216
The microbial transformation of anthranilic acid (1) by the marine-mudflat-derived fungus Thielavia sp. produced an antibacterial polycyclic quinazoline alkaloid, thielaviazoline (2). The stereostructure of the metabolite was assigned based on...
Induction of Apoptosis with Kigelia africana fruits in HCT116 Human Colon Cancer Cells via MAPKs Signaling Pathway

Guon TE, Chung HS

  • Nat Prod Sci.
  • 2016 Sep;22(3):209-215.
  • doi: 10.20307/nps.2016.22.3.209
Kigelia africana (Lam.) Benth. (Bignoniaceae) is a flowering plants in South, Central and West Africa and commonly known as the sausage tree (Eng.); worsboom (Afr.); umVunguta, umFongothi (Zulu); Modukguhlu (North...
Moringa oleifera Prolongs Lifespan via DAF-16/FOXO Transcriptional Factor in Caenorhabditis elegans

Im JS, Lee HN, Oh JW, Yoon YJ, Park JS, Park JW, Kim JH, Kim YS, Cha DS, Jeon H

  • Nat Prod Sci.
  • 2016 Sep;22(3):201-208.
  • doi: 10.20307/nps.2016.22.3.201
Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract of Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define the...
Bioassay-Guided Isolation and Identification of Compounds from Arecae Pericarpium with Anti-inflammatory, Anti-oxidative, and Melanogenesis Inhibition Activities

Indriana A, Lee KJ, Kim YS

  • Nat Prod Sci.
  • 2016 Sep;22(3):193-200.
  • doi: 10.20307/nps.2016.22.3.193
This study describes the anti-inflammatory, anti-oxidant, and melanogenesis inhibition activities of methanol extract and various organic solvent fractions of Arecae Pericarpium. We examined the inhibition of lipopolysaccharide (LPS)-induced nitric oxide...
Effects of Gypenosides on Dopaminergic Neuronal Cell Death in 6-Hydroxydopamine-lesioned Rat Model of Parkinson's Disease with Long-term L-DOPA Treatment

Shin KS, Zhao TT, Park HJ, Kim KS, Choi HS, Lee MK

  • Nat Prod Sci.
  • 2016 Sep;22(3):187-192.
  • doi: 10.20307/nps.2016.22.3.187
The goal of this study was to determine whether gypenosides (GPS) exert protective effects against dopaminergic neuronal cell death in a 6-hydroxydopamine (OHDA)-lesioned rat model of Parkinson's disease (PD) with...
Two-Week Repeated Dose Toxicity of Atractylodis Rhizoma Alba in F344 Rats

Han HY, Yang YS, Kim SN, Han SC, Lee JH, Jeong JY, Roh HS, Seok JH, Lee JS, Kim JA, Min BS

  • Nat Prod Sci.
  • 2016 Sep;22(3):180-186.
  • doi: 10.20307/nps.2016.22.3.180
This research is to estimate the toxicity of Atractylodis Rhizoma Alba (ARA) in F344 rats and to find a dose level for the 13 weeks toxicity study. A hot water...
Beneficial Effect of Lespedeza cuneata (G. Don) Water Extract on Streptozotocin-induced Type 1 Diabetes and Cytokine-induced Beta-cell Damage

Kim MS, Sharma BR, Rhyu DY

  • Nat Prod Sci.
  • 2016 Sep;22(3):175-179.
  • doi: 10.20307/nps.2016.22.3.175
The aim of this study was to evaluate the anti-diabetic effects of the water extract of Lespedeza cuneata (LCW) using rat insulinoma (RIN) m5F cells and streptozotocin (STZ)-induced diabetic rats....
Modulation of Melanin Synthesis by Amaranthus spp. L Seed Extract in Melan-a Cells

Seo JO, Do MH, Lee JH, Lee TH, Wahedi HM, Park YU, Kim SY

  • Nat Prod Sci.
  • 2016 Sep;22(3):168-174.
  • doi: 10.20307/nps.2016.22.3.168
Anti-melanogenic effects of amaranth (AT), one of the key source of squalene, were investigated in melanocytes. Amaranth seed powder was extracted with water and melan-a cells were treated with various...
Simultaneous Determination and Recognition Analysis of Coumarins in Angelica decursiva and Peucedanum praeruptorum by HPLC-DAD

Kim HM, Jeong SY, Kim SM, Lee KH, Kim JH, Seong RS

  • Nat Prod Sci.
  • 2016 Sep;22(3):162-167.
  • doi: 10.20307/nps.2016.22.3.162
Peucedani Radix is the root of Angelica decursiva Franchet et Savatier (=Peucedanum decursivum Maximowicz) or Peucedanum praeruptorum Dunn in several Asian countries. The coumarins contained in Peucedani Radix were quantitatively...
Chemical Constituents from Leaves of Pileostegia viburnoides Thoms

Li XJ, Liu ZZ, Kim KW, Wang X, Li Z, Kim YC, Yook CS, Liu XQ

  • Nat Prod Sci.
  • 2016 Sep;22(3):154-161.
  • doi: 10.20307/nps.2016.22.3.154
Phytochemical investigation on the leaves of Pileostegia viburnoides Thoms led to the isolation of twenty-five compounds, and their structures were identified as n-dotriacontane (1), taraxeryl acetate (2), friedelin (3),...
Anti-inflammatory Effect of Mangosteen (Garcinia mangostana L.) Peel Extract and its Compounds in LPS-induced RAW264.7 Cells

Widowati W, Darsono L, Suherman J, Fauziah N, Maesaroh M, Erawijantari PP

  • Nat Prod Sci.
  • 2016 Sep;22(3):147-153.
  • doi: 10.20307/nps.2016.22.3.147
Inflammation plays an important role in host defense against external stimuli such as infection by pathogen, endotoxin or chemical exposure by the production of the inflammatory mediators that produced by...

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