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CD24⁺ Cell Depletion Permits Effective Enrichment of Thymic iNKT Cells While Preserving Their Subset Composition

Park JY, Kwon J, Kim EY, Fink J, Kim HK, Park JH

Invariant NKT (iNKT) cells are a small subset of thymus-generated T cells that produce cytokines to control both innate and adaptive immunity. Because of their very low frequency in the...
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Lineage Differentiation Program of Invariant Natural Killer T Cells

Kwon DI, Lee YJ

Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which...
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Epstein-Barr Virus-Associated Vesiculopapular Eruption on the Face of a Patient with Natural Killer T Cell Lymphoma

Lim JS, Kim TM, Cho KH

Unlike typical hydroa vacciniforme (HV), Epstein-Barr virus (EBV)-associated HV-like eruption is more variable in its clinical manifestations. In some patients, progression to lymphoma or leukemia has been reported, which are...
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Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs

Bonamichi , Lee J

The notion that obesity-induced inflammation mediates the development of insulin resistance in animal models and humans has been gaining strong support. It has also been shown that immune cells in...
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Deficiencies of Circulating Mucosal-associated Invariant T Cells and Natural Killer T Cells in Patients with Multiple Trauma

Jo YG, Choi HJ, Kim JC, Cho YN, Kang JH, Jin HM, Kee SJ, Park YW

Mucosal-associated invariant T (MAIT) cells and natural killer T (NKT) cells are known to play important roles in autoimmunity, infectious diseases and cancers. However, little is known about the roles...
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Flagellin Modulates the Function of Invariant NKT Cells From Patients With Asthma via Dendritic Cells

Shim JU, Rhee JH, Jeong JU, Koh YI

PURPOSE: Invariant natural killer T (iNKT) cells play a critical role in the pathogenesis of asthma. We previously reported the association between circulating Th2-like iNKT cells and lung function in...
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Increased Th2-like Invariant Natural Killer T cells in Peripheral Blood From Patients With Asthma

Shim JU, Koh YI

PURPOSE: Invariant natural killer T (iNKT) cells might play an important role in asthma pathogenesis in humans. Our previous study found no difference in the number of blood iNKT cells...
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B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction

Shin JH, Park SH

CD1d expressing dendritic cells (DCs) are good glyco-lipid antigen presenting cells for NKT cells. However, resting B cells are very weak stimulators for NKT cells. Although alpha-galactosylceramide (alpha-GalCer) loaded B...
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Natural Killer T Cells in Acute and Unmedicated Patients with Major Depressive Disorder

Park EJ, Lee JH, Lee KH, Han SI, Jeon YW

  • KMID: 2341176
  • J Korean Neuropsychiatr Assoc.
  • 2006 May;45(3):208-213.
OBJECTIVES: To evaluate an association between depression and altered immunity, we examined peripheral T lymphocyte or natural killer (NK) cell measures plasma ACTH and cortisol using the flow cytometry in...
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The study on cytotoxicity of cytokines produced by the activated human NKT cells on neuroblastoma

Cho JY, Yoon YW, Yoon HS, Kim JD, Choi DY

PURPOSE: alpha-Galactosylceramide (alpha-GalCer)-stimulated human Valpha24 natural killer T (NKT) cells exert antitumor activity against some leukemia in a CD1d dependent and TCR-mediated manner, but could not kill CD1d-negative neuroblastoma (NB)...
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A Case of Natural Killer T-cell Lymphoma of the Tongue

Cho SG, Lee DH, Kim HR, Cho KJ

  • KMID: 2276199
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Aug;47(8):783-786.
Malignant lymphoma, which represents about 5.4% of all neoplasms and more significantly 19-28% of malignant neoplasms, is the most common non-epithelial malignancy in the head and neck area and non-Hodgkin's...
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Changes of Natural Killer T Cells in Behcet's Uveitis

Ahn JK, Yu HG, Kim YJ, Kim SJ, Yu YS, Chung H

  • KMID: 2206814
  • J Korean Ophthalmol Soc.
  • 2004 Aug;45(8):1356-1362.
PURPOSE: To determine the phenotypic and functional changes of circulating CD56+ T cells in ocular Behcet's disease (BD) according to the intraocular inflammatory activity METHODS: Forty patients with BD were...
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T Cell Receptor Rearrangement in NKT Cells Differentiated from Cord Blood CD34+ Cells

Jung YJ, Woo SY

OBJECTIVES: To investigate the time of rearrangement of the TCR gene in the process of NKT cell differentiation from CD34+ human cord blood cells in vitro. METHODS: We isolated the CD34+...
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The Development of NKT Cells in Thymus is Defective in CD45 Knockout Mice

Jung DH, Margulies

  • KMID: 1573065
  • Korean J Immunol.
  • 2000 Sep;22(3):117-121.
No abstract available.
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