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Concurrent Low Brain and High Liver Uptake on FDG PET Are Associated with Cardiovascular Risk Factors

Nam HY, Jun S, Pak K, Kim IJ

OBJECTIVE: Concurrent low brain and high liver uptake are sometimes observed on fluorine-18-labeled fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). We investigated the potential clinical significance of this uptake pattern related...
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Simple Purification of Adeno-Associated Virus-DJ for Liver-Specific Gene Expression

Liu J, Moon YA

Recombinant gene expression using adeno-associated viruses (AAVs) has become a valuable tool in animal studies, as they mediate safe expression of transduced genes for several months. The liver is a...
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Clinical implications of advances in liver regeneration

Kwon YJ, Lee KG, Choi D

Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better...
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Effects of resveratrol on the insulin signaling pathway of obese mice

Hong HJ, Kang W, Kim DG, Lee DH, Lee Y, Han CH

The present study was conducted to investigate the effects of resveratrol on the insulin signaling pathway in the liver of obese mice. To accomplish this, we administered resveratrol to high...
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Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

Koo SH

Liver plays a central role in the biogenesis of major metabolites including glucose, fatty acids, and cholesterol. Increased incidence of obesity in the modern society promotes insulin resistance in the...
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Hsp70 and HSF-1 expression is altered in the tissues of pigs transported for various periods of times

Zhang M, Yue Z, Liu Z, Islam A, Rehana B, Tang S, Bao E, Hartung J

The aim of this study was to assess changes of Hsp70 and HSF-1 protein and mRNA expression in stress-sensitive organs of pigs during transportation for various periods of time. Twenty...
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Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation

Kim HY, Cho HK, Yoo SK, Cheong J

  • KMID: 1506226
  • Exp Mol Med.
  • 2012 Oct;44(10):622-632.
Six transmembrane protein of prostate 2 (STAMP2) plays a key role in linking inflammatory and diet-derived signals to systemic metabolism. STAMP2 is induced by nutrients/feeding as well as by cytokines...
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CD44 Disruption Attenuates Murine Hepatic Ischemia/Reperfusion Injury

Kim MS, Lee KH, Lee WM, Jun JH, Kim DH

Neutrophil adhesion and migration are critical in hepatic ischemia/reperfusion (I/R) injury. Despite very strong preclinical data, recent clinical trials failed to show a protective effect of anti-adhesion therapy in reperfusion...
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Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms

Park WH, Pak YK

Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various...
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Bioelectrical Impedance May Predict Cell Viability During Ischemia and Reperfusion in Rat Liver

Cui ML, Ahn HS, Kim JY, Shin HJ, Lee DS, Kim HJ, Yun SS

Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but no method could monitor or predict it real-time during surgery. We measured bioelectrical impedance...
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Tissue-specific activation of mitogen-activated protein kinases for expression of transthyretin by phenylalanine and its metabolite, phenylpyruvic acid

Park JW, Lee MH, Choi JO, Park HY, Jung SC

Phenylketonuria is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase. Transthyretin has been implicated as an indicator of nutritional status in phenylketonuria patients. In this study, we...
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Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells

Min G

The nuclear receptors, steroid and xenobiotic receptor (SXR) and constitutive androstane receptor (CAR) play important functions in mediating lipid and drug metabolism in the liver. The present study demonstrates modulatory...
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Wilson Disease: an Update

Seo JK

  • KMID: 760667
  • Korean J Hepatol.
  • 2006 Sep;12(3):333-363.
Wilson disease (WD) is an autosomal recessive disorder of copper transport that results in accumulation of copper primarily in the liver, the brain and the cornea. WD is the most...
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Association of Hepatic Iron Deposition and Serum Iron Indices with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease

Moon JH, Park SH, Oh KC, Jung JO, Shin WG, Kim JP, Kim KO, Park CH, Hahn T, Yoo KS, Kim JH, Kim DJ, Lee MS, Park CK, Jun SY

  • KMID: 772970
  • Korean J Gastroenterol.
  • 2006 Jun;47(6):432-439.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty liver and progress to severe liver disease such as cirrhosis. The mechanism determining the progression from fatty liver to steatohepatitis is...
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Protein Expression Profiles in a Rat Cirrhotic Model Induced by Thioacetamide

An JH, Seong J, Oh H, Kim W, Han KH, Paik YH

  • KMID: 760634
  • Korean J Hepatol.
  • 2006 Mar;12(1):93-102.
BACKGROUND/AIMS: The reactive oxygen species from thioacetamide (TAA) induces rat liver cirrhosis that resembles the human disease, and it can serve as a suitable animal model for studying human...
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Insulin Resistance in Non-Alcoholic Fatty Liver Disease

Park JH

  • KMID: 760627
  • Korean J Hepatol.
  • 2006 Mar;12(1):16-30.
Insulin resistance is the pathophysiological hallmark of various kinds of clinical diseases, including non- alcoholic fatty liver disease. Insulin resistance is the common characteristic of metabolic syndrome and its related...
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Antioxidant Status in Nonalcoholic Steatohepatitis

Park KS, Jang BK, Kwon KM, Chung WJ, Cho KB, Hwang JS, Ahn SH, Mun KC, Kim YH

  • KMID: 760591
  • Korean J Hepatol.
  • 2005 Jun;11(2):135-143.
BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is chronic liver disease that can potentially progress to end stage liver disease. Oxidative stress to the vulnerable fatty liver has been reported as a...
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Effects of Vitamin E Supplementation on Oxidative Stress in Streptozotocin Induced Diabetic Rats: Investigation of Liver and Plasma

Seven A, Guzel S, Seymen O, Civelek S, Bolayirli , Uncu M, Burcak G

This experimental study was designed to investigate the effects of vitamin E supplementation, especially on lipid peroxidation and antioxidant status elements3/4namely, glutathione (GSH), CuZn superoxide dismutase (CuZn SOD), and glutathione...
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Activation of calcium signaling by hepatitis B virus-X protein in liver cells

Oh JC, Jeong DL, Kim IK, Oh SH

  • KMID: 1109320
  • Exp Mol Med.
  • 2003 Aug;35(4):301-309.
Hepatitis B virus x gene product (HBx) is known to be a transactivator of transcriptional elements that regulate the expression of a variety of genes associated with the growth, differentiation,...
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Gene Delivery to the Rat Liver Using Cationic Lipid Emulsion/DNA Complex: Comparison between Intra-arterial, Intraportal and Intravenous Administration

Choi BY, Chung JW, Park JH, Kim KH, Kim YI, Koh YH, Kwon JW, Lee KH, Choi HJ, Kim TW, Kim YJ, Chung H, Kwon IC, Jeong SY

OBJECTIVE: To compare the efficiency of intra-arterial, intraportal, and intravenous administration of cationic lipid emulsion/DNA complex, as used for gene transfer to rat liver. MATERIALS AND METHODS: DNA-carrier complex for the...
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