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Effect of cumulative exposure to tacrolimus on the recurrence of hepatocellular carcinoma after liver transplantation

Kim DG, Lee JG, Joo DJ, Kim MS

Background: Previous studies reported that maintaining at lower trough level of tacrolimus could reduce the recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT); however, this has never been assessed...
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Antiplatelet drugs on the recurrence of hepatocellular carcinoma after liver transplantation

Kim DG, Choi MC, Min EK, Lee JG, Joo DJ, Kim MS

Background: Previous studies reported suppressive effects of antiplatelet agents on hepatocellular carcinoma (HCC); however, this has never been assessed in patients who underwent liver transplantation (LT). Methods: This retrospective observational study...
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Second hand allotransplantation experience after the revised transplantation law: 5-month follow-up

Kim Y, Hong JW, Lee SJ, Kim SH, Jwa SJ, Joo OY, Mo YW, Suh YC, Choi YR, Joo DJ

Background: Hand transplantation for upper extremity amputation provides a unique treatment that restores form and function. In January 2021, the first hand allotransplantation since legalization was successfully performed. Based on...
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Posttransplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation: a nationwide cohort study in Korea

Ihn K, Hahn SM, Lee M, Kim EH, Kang JM, Lim SM, Joo DJ, Jung I

Background: osttransplant lymphoproliferative disorders (PTLD) are the majority of cancer diagnoses after solid organ trans-plantation (SOT) and allogeneic hematopoietic stem cell transplantation (HSCT) with a high incidence of PTLD developed...
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Impact of everolimus versus mycophenolate mofetil in combination with reduced tacrolimus in liver transplantation patients with hepatocellular carcinoma within Milan criteria

Min EK, Lee JG, Choi MC, Yim SH, Kim DG, Joo DJ

Background: The benefit of using everolimus with reduced tacrolimus (rTAC) in respect of hepatocellular carcinoma (HCC) recurrence is still controversial and whether preventive effect of HCC recurrence resulted from everolimus...
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Clinical impact of myosteatosis in liver transplant recipients

Lee J, Koh HH, Min E, Yim SH, Choi M, Kim DG, Lee JG, Joo DJ

Background: Myosteatosis, excessive intramuscular fat disposition, is common in patients with chronic liver disease and is associated with increased morbidity and mortality. We investigated the effects of pretransplant myosteatosis on...
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Initial high anti-ABO isoagglutinin titer is a major red flag of bacterial infection in ABO-incompatible living donor liver transplantation

Choi MC, Min EK, Yim SH, Kim DG, Lee JG, Joo DJ, Kim MS

Background: Many previous studies showed comparable clinical outcomes of ABO-incompatible (ABOi) living donor liver trans-plantation (LDLT) compared to ABO-compatible (ABOc) LDLT, but there were few studies related to initial high...
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The unusual grafts for living donor liver transplantation

Yim SH, Min EK, Choi MC, Kim DG, Lee JG, Han DH, Joo DJ, Choi GH, Kim MS

Background: To find an adequate graft for living donor liver transplantation (LDLT), the left lobe and the right lobe grafts of the liver were introduced. However, the left lobe graft...
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Clinical association between tacrolimus intra-patient variability and liver transplantation outcomes in patients with and without hepatocellular carcinoma

Kim HJ, Lee JG, Joo DJ, Kim MS, Lee J

Tacrolimus is the mainstay of immunosuppression in liver transplantation to prevent rejection. However, the clinical use of tacrolimus is complicated by its narrow therapeutic window and significant intra-patient variability (IPV)....
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Diagnostic role of tumor markers for hepatocellular carcinoma in liver transplantation candidates: an analysis using Korean Organ Transplantation Registry database

Hwang S, Kang WH, Kim JM, Lee KW, Joo DJ, You YK, Ryu JH, Kim BW, Choi D, Kim DS

Background: This study intended to analyze pretransplant alpha-fetoprotein (AFP) and proteins induced by vitamin K absence or antagonist-II (PIVKA-II) in liver transplantation (LT) candidates. Methods: A total of 3,273 LT recipients...
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Analysis of posttransplant hepatocellular carcinoma prognosis using ADV score: a validation multicenter study

Hwang S, Park GC, You YK, Choi Y, Kim JM, Joo DJ, Ryu JH, Choi D, Kim BW, Kim DS

Background: ADV score (α-fetoprotein [AFP]–des-γ-carboxyprothrombin [DCP]–tumor volume [TV] score) has been reported as a prognostic surrogate biomarker of hepatocellular carcinoma (HCC) following liver transplantation (LT) and hepatectomy. This study aimed to...
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Comparison of humoral immunogenicity in solid organ transplant recipients after third-dose mRNA vaccine with homologous or heterologous schedules: an observational study

Kang J, Lee J, Huh KH, Joo DJ, Lee JG, Jung I, Kim S, Park Y, Kim MS

Background: Solid organ transplant recipients (SOTRs) are susceptible to severe coronavirus disease 2019 (COVID-19) and im-munogenicity studies of Omicron variants according to vaccination schedules are lacking. We examined the humoral...
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The effect of donor against recipient one-way human leukocyte antigen mismatch on liver transplantation outcomes: an analysis of Korean Organ Transplantation Registry (KOTRY) Database

Park S, Rhu J, Kim DS, Choi Y, Joo DJ, You YK, Kim BW, Nah YW, Cho JY, Kim TS

Background: Donor against recipient (D-R) one-way human leukocyte antigen (HLA) mismatch (MM) seemed strongly associated with graft-versus-host disease (GVHD) after liver transplantation (LT). The aim of this study is to...
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Antitumor Effect of Low-Dose of Rapamycin in a Transgenic Mouse Model of Liver Cancer

Lee HS, Kim JY, Ro SW, Kim MS, Kim H, Joo DJ

Purpose: We investigate whether low-dose rapamycin is effective in preventing hepatocellular carcinoma (HCC) growth and treating HCC after tumor development in transgenic mice. Materials and Methods: We established transgenic mice with...
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Circulating Cancer Stem Cells Expressing EpCAM/CD90 in Hepatocellular Carcinoma: A Pilot Study for Predicting Tumor Recurrence after Living Donor Liver Transplantation

Hwang HS, Yoo JE, Han DH, Choi JS, Lee JG, Joo DJ, Kim MS, Kim SI, Choi GH, Park YN

Background/aims: Circulating tumor cells (CTCs) with cancer stemness have been demonstrated to be a direct cause of tumor recurrence, and only few studies have reported the role of CTCs in...
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Pre- and post-transplant risk factors for renal dysfunction in the patients with preserved renal function at 1 month after liver transplantation: a national cohort study using Korean Organ Transplantation Registry (KOTRY)

Kim DG, Lee JG, Kim MS, Joo DJ

Background: Renal dysfunction (RD) is an important long-term complication after liver transplantation (LT) which is associated with patient survival. This study investigated pre- and post-transplant risk factors for RD in...
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Differential impact of tacrolimus intra-patient variability on liver transplant outcomes in patients with and without hepatocellular carcinoma

Kim HJ, Lee JG, Joo DJ, Kim MS, Kim SI, Lee J

Background: The recurrence rate for hepatocellular carcinoma (HCC) after liver transplant is high as 15%–20% despite a careful selection of candidates. Although immunosuppression plays an important role in post-transplant HCC...
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Pancreaticoduodenectomy with combined hepatic artery and portal vein resection after laparoscopic division of pancreaticosplenic ligament due to FOLFIRINOX-induced hepatic toxicity related secondary hypersplenism

Kim JS, Park JY, Choi M, Joo DJ, Hwang HK, Lee WJ, Kang CM

Pancreatic cancer is one of the dismal malignant disease in gastrointestinal tract. However, since the recent literature reporting median survival of FOLFIRINOX (leucovorin clcium, fluorouracil, irinotecan hydrochloride, oxaliplatin) chemotherapy was...
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Current Status of Deceased Donor Liver Transplantation for Alcoholic Liver Disease in Korea in MELD Era

Joo DJ

The organ allocation system should be fair and efficient to predict the prognosis of patients with end-stage organ failure. The liver allocation system in Korea was changed to the model...
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The feasibility of organ transplantation during the COVID-19 outbreak: experiences from South Korea

Lee J, Kim EJ, Ihn K, Lee JG, Joo DJ, Kim MS, Kim SI, Kim YS, Huh KH

Background: The coronavirus disease 2019 (COVID-19) has forced healthcare systems to reduce transplant activities in order to preserve resources and minimize the risk of nosocomial transmission. Although transplantation societies around...
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