J Korean Soc Transplant.  2010 Jun;24(2):87-92. 10.4285/jkstn.2010.24.2.87.

Clinical Characteristics of Focal Segmental Glomerulosclerosis Recurrence after Adult Renal Transplantation

• Joo DJ
• Lee JJ
• Lee BM
• Kim MS
• Huh KH
• Kim SJ
• Kim SI
• Kim YS

• KMID: 1457128
• DOI: http://doi.org/10.4285/jkstn.2010.24.2.87

Abstract

BACKGROUND
Recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is a frequent and still unpredictable complication. Moreover, risk factors for recurrence have not yet been clearly identified.
METHODS
We enrolled into our study 2,882 adult kidney recipients who underwent transplantation between April 1979 and April 2009. We retrospectively reviewed clinical manifestations of recurrence of FSGS.
RESULTS
Among the 2,784 adult renal recipients, forty four had undergone renal transplantation for primary FSGS. Of the 44, 12 (27.3%) showed recurrent FSGS. Mean duration between transplantation and FSGS recurrence was 22.8+/-37.4 months. There were no significant differences in patient characteristics in the recurrence and non-recurrence groups. The cumulative incidence of FSGS recurrence was 13.8% within 1 year after kidney transplantation and 23.2% within 3 years. The overall graft survival rate in the recurrence group was significantly lower than that of the non-recurrence group (P=0.0018) and non-FSGS group (P=0.0001). Graft failure happened more in the recurrence group (75%) than in the non-recurrence group (37.5%, P=0.042).
CONCLUSIONS
We failed to find any significant risk factors for FSGS recurrence after renal transplantation.

Keyword

Focal segmental glomerulosclerosis; Kidney transplantation; Risk factors; Recurrence

MeSH Terms

Adult
Glomerulosclerosis, Focal Segmental
Graft Survival
Humans
Incidence
Kidney
Kidney Transplantation
Recurrence
Retrospective Studies
Risk Factors
Transplants
Glomerulosclerosis, Focal Segmental

Reference

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