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The Consideration for an Unlikely Culprit Drug (Betahistine) Inducing Toxic Epidermal Necrolysis: A Case Report

Ikegami T, Hayashi S, Okamoto M, Kanai J, Kaneko Y, Saito Y, Kaminaga T, Hamasaki Y, Igawa K

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Development and growth of the human fetal sacroiliac joint revisited: a comparison with the temporomandibular joint

Kim JH, Jin ZW, Hayashi S, Murakami G, Abe H, Rodríguez-Vázquez JF

The human fetal sacroiliac joint (SIJ) is characterized by unequal development of the paired bones and delayed cavitation. Thus, during the long in utero period, the bony ilium becomes adjacent...
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In utero hematopoietic stem cell therapy

Hayashi S, Flake AW

In utero hematopoietic stem cell transplantation (IUHSCTx) is a promising approach for the treatment of a potentially large number of fetuses affected by congenital hematologic disorders. With technical advances in...
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The effect of dichlorotriazinyl aminofluorescein on human keratocytes in vitro

Wee WR, Rofougaran R, Pakkar A, Hayashi S, McDonnell

Dichlorotriazinyl aminofluorescein (DTAF) has been used to stain corneal stromal collagen as part of in vivo animal experiments for many years. Toxicity of this drug, if present, might alter the...
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Umbilical cord vessels other than the umbilical arteries and vein: a histological study of midterm human fetuses

Kim JH, Hayashi S, Jin ZW, Murakami G, Rodríguez-Vázquez JF

At birth, the umbilical cord contains various types of thin vessels that are near and outside the umbilicus and separate from the umbilical arteries and vein. These vessels are regarded...
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Influence of developing ligaments on the muscles in contact with them: a study of the annular ligament of the radius and the sacrospinous ligament in mid-term human fetuses

Hayashi S, Kim JH, Rodriguez-Vazquez JF, Murakami G, Fukuzawa Y, Asamoto K, Nakano T

The supinator muscle originates from the annular ligament of the radius, and the muscle fibers and ligament take a similar winding course. Likewise, the coccygeus muscle and the sacrospinous ligament...
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Distally-extending muscle fibers across involved joints: study of long muscles and tendons of wrist and ankle in late-term fetuses and adult cadavers

Wang S, Hayashi S, Jin ZW, Kim JH, Yamamoto M, Murakami G, Abe S

It is unclear whether forearm and crural muscle fibers extend distally across the wrist and ankle joints, respectively. We hypothesized, in late-term fetuses, an over-production of muscle bellies extending over the...
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Spatial relationship between expression of cytokeratin-19 and that of connexin-43 in human fetal kidney

Hieda K, Hayashi S, Kim JH, Murakami G, Cho BH, Matsubara

Connexin-43, a major gap junction protein, and cytokeratin-19, one of the intermediate filament keratins, are known to be markers of well-differentiated epithelium. In this study, we investigated the expression of...
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Fetal cervical zygapophysial joint with special reference to the associated synovial tissue: a histological study using near-term human fetuses

Kitamura K, Hayashi S, Jin ZW, Yamamoto M, Murakami G, Rodríguez-Vázquez JF, Yamamoto H

Human fetal cervical vertebrae are characterized by the large zygapophysial joint (ZJ) extending posteriorly. During our recent studies on regional differences in the shape, extent, and surrounding tissue of the...
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Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 (Cdx2) Transgenic Mice

Sakamoto H, Asahara T, Chonan O, Yuki N, Mutoh H, Hayashi S, Yamamoto H, Sugano K

BACKGROUND/AIMS: Caudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach. Atrophic gastritis and intestinal metaplasia commonly...
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Accurate and Easy Measurement of Sliding Distance of Intramedullary Nail in Trochanteric Fracture

Chinzei N, Hiranaka T, Niikura T, Fujishiro , Hayashi S, Kanzaki N, Hashimoto , Sakai Y, Kuroda R, Kurosaka M

BACKGROUND: In daily clinical practice, it is essential to properly evaluate the postoperative sliding distance of various femoral head fixation devices (HFD) for trochanteric fractures. Although it is necessary to...
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TP53 variants in p53 signatures and the clonality of STICs in RRSO samples

Akahane T, Masuda K, Hirasawa A, Kobayashi Y, Ueki A, Kawaida M, Misu K, Nakamura K, Nagai S, Chiyoda T, Yamagami W, Hayashi S, Kataoka F, Banno K, Sugano K, Okita H, Kosaki K, Nishihara H, Aoki D

Objective Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of BRCA1/2. Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of...
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Heterogeneity of glandular cells in the human salivary glands: an immunohistochemical study using elderly adult and fetal specimens

Katori Y, Hayashi S, Takanashi , Kim JH, Abe S, Murakami G, Kawase T

Using immunohistochemical staining for alpha-smooth muscle actin (alpha-SMA), glial fibrillary acidic protein (GFAP), S100 protein (S100), p63, cytokeratin 14 (CK14), and cytokeratin 19 (CK19), we studied acinar and myoepithelial cells...
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