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Distribution of adeG, adeB, adeE, adeY, abeM, and adeJ Efflux Pump Genes in Clinical Isolates of Acinetobacter Species from Korea

Choi IS, Choi JA, Jang SJ, Park G, Jeong SH, Kim CM, Lee OJ, Kang SH, Moon DS

BACKGROUND: The aim of the present study was to determine the frequency of six efflux pump genes in Acinetobacter clinical isolates collected from South Korean hospitals. METHODS: In this study, we...
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Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China

Yan J, Pu S, Jia X, Xu X, Yang S, Shi J, Sun S, Zhang L

BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR...
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A Study of Efflux Pump Genes in Mycobacterium tuberculosis Clinical Isolates

Cho SY, Nam YS, Yang HS, Soh YS, Kim MJ, Lee HJ

The efflux pump system has been suggested as an important mechanism in the drug resistance of Mycobacterium tuberculosis (MTB). In this study, molecular analysis of five genes in the efflux...
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Molecular Characteristics of blaOXA-23-Producing Acinetobacter baumannii Isolated from a University Hospital

Jang IH, Park SD, Uh Y, Lee GS, Kim JB, Choi I

BACKGROUND: Multi-drug resistant (MDR) Acinetobacter baumannii has emerged as a significant infectious agent in hospitals worldwide. The purpose of this study was to determine the molecular characterization of MDR A....
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Epileptogenic Properties of Balloon Cells in Cortical Tubers of Tuberous Sclerosis: Upregulation of Drug Resistance Proteins

Kang NG, Chang HJ, Ok YC, Lee RS, Park SK, Lim JS, Cho KY, Kim HI, Kim JH, Oh HS, Lee MC

  • KMID: 1956262
  • J Korean Neurosurg Soc.
  • 2007 Jun;41(6):397-402.
OBJECTIVES: Balloon cells and dysplastic neurons are histopathological hallmarks of the cortical tubers of tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) of the Taylor type. They are believed...
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Decoy Oligonucleotides on Which Nuclear Factor for YB-1 Bind Inhibit the Growth of Cancer Cells

Han SW, Lee WS, Park CH, Kim HS, Choi SK, Rew JS, Lee SR, Li LH, Kim SJ, Chung SS, Shin BA

  • KMID: 1514203
  • Chonnam Med J.
  • 2006 Aug;42(2):85-93.
Human YB-1 is a transcription factor binding on the inverted CCAAT box in the promoter region of various genes such as PCNA, DNA polymerase and MDR genes. We previously reported...
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Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia

Huh HJ, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T

The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression...
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A role of Cyclosporine A that suppresses multi-drug resistance (MDR) in the secondary chemotherapy drug resistant cell line of ovarian cancer

An CS, Kim SY, Park CM

  • KMID: 2143513
  • Korean J Gynecol Oncol.
  • 2006 Dec;17(4):286-293.
OBJECTIVE: Resistant, recurrent ovarian cancer patients who had first chemotherapy with Cisplatin have showed low reactivity and high recurrence in the secondary chemotherapy. Therefore, multi-drug resistance (MDR) to chemotherapy is...
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Is C3435T Polymorphism of MDR1 Related to Inflammatory Bowel Disease or Colorectal Cancer in Korean?

Lee BI, Choi KY, Lee KM, Chung WC, Kim BW, Choi H, Cho SH, Kang HJ, Lee JS, Kim MS, Chae HS, Chun IS

  • KMID: 1079900
  • Korean J Gastroenterol.
  • 2006 Jan;47(1):22-29.
BACKGROUND/AIMS: Multidrug resistance 1 (MDR1) gene encodes P-glycoprotein in intestinal epithelium, which serves as a transmembrane efflux pump of various toxins. mdr1 knockout mice develop spontaneous colitis under specific...
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Relation among the Tests and Comparison of Positivity of Tests for Multi-Drug Resistance in Newly Diagnosed Acute Leukemia

Lee NY, Bae HG, Kwon EH, Heo WB, Shin SH, Suh JS

  • KMID: 2239566
  • Korean J Lab Med.
  • 2003 Jun;23(3):143-150.
BACKGROUND: The expression of multi-drug resistance (MDR) in acute leukemia was known to decrease the outcome of chemotherapy and to increase the rate of relapse. Of the mechanism of MDR,...
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The Cytotoxic and Radiosensitizing Effects of Taxol in Uterine Sarcoma Cell Lines

Lee HY, Park DC, Kim SW, Lew YO, Kim DH

  • KMID: 2272001
  • Korean J Obstet Gynecol.
  • 2003 Apr;46(4):725-731.
OBJECTIVE: The cytotoxic and radiosensitizing effects of Taxol in uterine sarcoma cell lines were investigated. METHODS: Two uterine sarcoma cell lines with different Taxol responses were used, namely, Taxol- sensitive and...
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Expression of Multidrug Resistance Genes, mdr1, mrp, Topo IIalpha and Topo IIbeta in Childhood Acute Lymphoblastic Leukemia

Lim SH, Ko DH, Kook H, Yoon WS, Kim HJ, Kim SY, Kim CJ, Hwang TJ

  • KMID: 2140617
  • Korean J Pediatr Hematol Oncol.
  • 2002 Apr;9(1):82-90.
PURPOSE: Multidrug resistance in the treatment of cancer mediated by several drug resistant genes impedes the successful management of cancer. The authors investigated the expression of drug resistant genes,...
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Multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) gene expression in osteosarcoma and their prognostic significance

Jung HG, Lee SH, Kim HS

  • KMID: 2105711
  • J Korean Orthop Assoc.
  • 2001 Feb;36(1):1-8.
PURPOSE: The purpose of this study is to evaluate the correlations between the multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) gene in osteosarcoma, and their prognostic significances by RT-PCR...
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Multi-drug resistance (MDR1) gene expression in de novo acute leukemia cells: correlations with CD surface markers and treatment outcome

Jiang EZ, Chang YJ, Lee JW, Lee WK, Kim JS, Sohn SK, Lee KB, Suh JS

One important mechanism of drug resistance in acute leukemia is the overexpression of the multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P-glycoprotein. To estimate the...
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Expression of Glutathione-S-Transferase and P-glycoprotein in Human Cervical Cancer

Byun TS, Bae SN, Kim YW, Chang BW, Kim DK, Kim SP

  • KMID: 1855594
  • Korean J Obstet Gynecol.
  • 1998 Jan;41(1):10-16.
Expression of glutathione-S-transferase-pai and multidrug resistance gene was examined immunohistochemically in relation to the response to neoadjuvant chemotherapy with cisplatin and etoposide in 23 patients with primary squamous cell carcinoma...
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The Effect of Medroxyprogesterone Acetate On Cytotoxicity of Vinblastine in Renal Cell Carcinoma Cell Lines

Lee DH, Chung BH, Hong SJ

  • KMID: 1914473
  • Korean J Urol.
  • 1997 Jan;38(1):1-6.
Inadequate effectiveness of anticancer drug in treating renal cell carcinoma has been attributed to the overexpression of multidrug resistance gene (MDR1) and its product, membrane-bound P-glycoprotein. P-glycoprotein is known to...
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Expression of Multidrug Resistance Gene Product in Laryngeal Squamous Cell Carcinoma

Chung SM

OBJECTIVES: Various mechanisms are involved in drug resistance of tumor cells. Among them one such mechanism is the overexpression of the multidrug resistance(mdr1) gene product P-glycoprotein(Pgp) that functions as an...
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Change of MDR Gene Expression and Glutathione Metabolism during Long Standing Low-dose Cisplatin Exposure in Bladder Carcinoma Cell Line

Lee ES, Kim SW, Yoon SJ, Lee HW, Ahn HJ, Lee CW

  • KMID: 1663273
  • Korean J Urol.
  • 1996 Dec;37(12):1345-1350.
Resistance to anticancer chemotherapeutic drugs remains a major obstacle in cancer chemotherapy. A variety of mechanisms responsible for drug resistance has been posed. Mdr gene overexpression and detoxification by glutathione...
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The Effect of Multidrug Resistance Modulators on Cytotoxicity of Adriamycin upon Human Renal Cell Carcinoma Cell Lines

Kim HH, Ahn HJ, Song K, Lee ES, Lee CW

  • KMID: 1913725
  • Korean J Urol.
  • 1994 Jan;35(1):1-12.
It is well known that renal cell carcinoma shows poor responses upon chemotherapy, and a multidrug-resistance has been suggested as one of the possible mechanisms of these resistances to chemotherapeutics...
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Correlation of multidrug resistance gene expression with hestologic grade in locally advanced breast cancer

Bae JW, Kim IS, Hwang JW

  • KMID: 1694328
  • J Korean Cancer Assoc.
  • 1993 Jun;25(3):376-382.
No abstract available.
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