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T Cell Mediated Drug Hypersensitivity: Stevens Johnson Syndrome and Toxic Epidermal Necrolysis

  • KMID: 2234604
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Jun;29(2):79-87.
No abstract available.
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A Case of Toxic Epidermal Necrolysis Associated with Chronic Pulmonary Complications

Choi YJ, Lee SJ, Lee GY, Kim KJ

  • KMID: 2247767
  • Korean J Dermatol.
  • 2009 Sep;47(9):1034-1038.
Toxic epidermal necrolysis (TEN) is an unpredictable, acute inflammatory systemic condition that involves injury to the skin, mucous membranes, and bowel and respiratory epithelium. Pulmonary complications are often observed and...
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Toxic Epidermal Necrolysis with Ocular Involvement Following Vaccination for Hemorrhagic Fever with Renal Syndrome

Hwang YH, Kang MS, Lim KO, Lee SM

We report a case of toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. A healthy 20-year-old male soldier presented with confluent purpuric and erythematous...
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Toxic Epidermal Necrolysis Induced by the Topical Carbonic Anhydrase Inhibitors Brinzolamide and Dorzolamide

Chun JS, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC

Brinzolamide and dorzolamide are highly specific topical carbonic anhydrase inhibitors (CAIs). They lower intraocular pressure (IOP) by reducing the rate of aqueous humour formation without serious side effects. Although systemic...
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Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma

Choi MK, Woo HY, Heo J, Cho M, Kim GH, Song GA, Kim MB

This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib...
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Toxic Epidermal Necrolysis by Ceftriaxone in Patient with Newly Diagnosed Systemic Lupus Erythematosus

Lee JH, Ju IN, Cho HJ, Min HK, Hong YS

Toxic epidermal necrolysis (TEN) is a rare disease in absolute numbers with an incidence of 2 cases per million people per year. Most cases of TEN are caused by drugs,...
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Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome Caused by Topical Ophthalmic Use of Dorzolamide

Kim JW, Shin SY

  • KMID: 2247975
  • Korean J Dermatol.
  • 2009 Mar;47(3):317-321.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the potentially life-threatening, acute hypersensitivity reaction to inciting drugs. These diseases have been often associated with systemic carbonic anhydrase inhibitor such...
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Anesthetic management for emergent Cesarean section in a patient with toxic epidermal necrolysis: A case report

Lee JH, Yang HJ, Yang BK, Lee SY, Park C, Kim DH

Toxic epidermal necrolysis (TEN) is rare but serious cutaneous reaction with significant mortality and long-term morbidity. Various etiologies, particularly numerous medications and infectious agents have been implicated. It is characterized...
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Isolation of Enterovirus Type 71 in a 3-year-old Boy Suffering from Toxic Epidermal Necrolysis

Han SM, Han SH, Song JW, Lee YH, Park KS, Park JS

  • KMID: 2314883
  • Pediatr Allergy Respir Dis.
  • 2008 Jun;18(2):189-193.
Toxic epidermal necrolysis (TEN) is an exfoliative disease of skin and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results...
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A case of steroid-induced psychosis in a child having nephrotic syndrome with toxic epidermal necrolysis

Kim SY, Lee JM, Park YH

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare, life-threatening mucocutaneous diseases, usually attributable to drugs and infections. Corticosteroids have been used in the management of TEN for the...
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Chronic pulmonary complications due to toxic epidermal necrolysis

Hwang SH, Kim DH, Kim JH, Son BK, Lim DH

Toxic epidermal necrolysis (TEN) is the most severe form of skin reactions caused by drugs or infection. Acute pulmonary complications in TEN are often observed. The mortality is especially high...
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Toxic Epidermal Necrolysis after Rituximab Therapy for Immune Thrombocytopenic Purpura

Bae SY, Kim YK, Yoon JY, Lee SJ, Kim DE, Rew SY, Hong SD, Jo DH, Hwang JI, Bae WK, Shim HJ, Ahn JS, Yang DH, Cho SH, Lee JJ, Chung IJ, Kim HJ

Rituximab is a chimeric monoclonal antibody that specifically targets the CD20 molecule on the B cell surface. Although rituximab was originally introduced for the treatment of lymphoid neoplasms such as...
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High-Dose Intravenous Immunoglobulin in the Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

  • KMID: 2346807
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Dec;29(4):256-261.
BACKGROUND: There have been some uncontrolled studies on clinical efficacy of high-dose intravenous immunoglobulin (IVIG) in patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). OBJECTIVE: This study was conducted...
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A Case of Stevens-Johnson Syndrome with Acute Renal Failure Induced by Rhus-Chicken Ingestion

Kang DY, Kim MS, Yoon SS, Yun TS, Jeong DI, Seol HY, Lee YK

  • KMID: 2264128
  • Korean J Med.
  • 2011 Nov;81(5):680-684.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, diffuse mucocutaneous reactions that can be elicited by drugs, infection, malignancy, and herbal supplements. A wide variety of mucocutaneous events,...
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Update on the Management of Antibiotic Allergy

Thong BY

Drug allergy to antibiotics may occur in the form of immediate or non-immediate (delayed) hypersensitivity reactions. Immediate reactions are usually IgE-mediated whereas non-immediate hypersensitivity reactions are usually non-IgE or T-cell...
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A Case of Toxic Epidermal Necrolysis (TEN) Induced by Nonsteroidal Anti-Inflammatory Drug (NSAID)

Kim SP, Choi YG, Kim SJ, Cho SH, Cho NS

  • KMID: 2332604
  • J Korean Soc Emerg Med.
  • 2009 Apr;20(2):227-230.
A patient who was transferred to our Emergency Medical Center from a local clinic with a dermatologic disorder of unknown origin presented to us with TEN with a 40% skin...
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Causes and Treatment Outcomes of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in 82 Adult Patients

Kim HI, Kim SW, Park GY, Kwon EG, Kim HH, Jeong JY, Chang HH, Lee JM, Kim NS

BACKGROUND/AIMS: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are predominantly known as medication-induced diseases. However, at our institution, we have experienced more cases of non-drug-related SJS and TEN than...
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A Clinical Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Efficacy of Treatment in Burn Intensive Care Unit

Yim H, Park JM, Cho YS, Kim D, Hur J, Chun W, Kim JH, Seo DK

PURPOSE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), potentially life-threatening skin diseases with organ failures caused by drugs, require specialized intensive care. However, SJS and TEN have usually been...
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Clinical Features and Etiology of Adult Patients with Fever and Rash

Tabak F, Murtezaoglu A, Tabak O, Ozaras R, Mete B, Kutlubay Z, Mert A, Ozturk R

BACKGROUND: Patients with fever and rash often pose an urgent diagnostic and therapeutic dilemma for the clinician. The nonspecificity of many fever and rash syndromes mandates a systemic approach to...
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Clinical Features of Adverse Drug Reactions in a Tertiary Care Hospital in Korea

  • KMID: 2234478
  • Korean J Asthma Allergy Clin Immunol.
  • 2008 Mar;28(1):35-39.
BACKGROUND: Clinical features of adverse drug reactions (ADR) are different and the incidence is increasing. However, there have been only a few data on the clinical features of ADR in...
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