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Sclerostin as a Putative Myokine in Sarcopenia

Yi HS

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Extra-Glycemic Effects of Anti-Diabetic Medications: Two Birds with One Stone?

Rhee EJ

The world is suffering from a rapid increase in the number of people with diabetes due to the increased prevalence of obesity and lengthened life span. Since the development of...
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Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia

Ahn SH, Jung HW, Lee E, Baek JY, Jang IY, Park SJ, Lee JY, Choi E, Lee YS, Hong S, Kim BJ

Background: Although muscles and bones interact with each other through various secretory factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not been well studied. We investigated...
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The Impact of Insulin Resistance on Hepatic Fibrosis among United States Adults with Non-Alcoholic Fatty Liver Disease: NHANES 2017 to 2018

Bae JC, Beste LA, Utzschneider KM

Background: We aimed to investigate the association of hepatic steatosis with liver fibrosis and to assess the interactive effects of hepatic steatosis and insulin resistance on liver fibrosis in a...
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Bone Mineral Density Screening Interval and Transition to Osteoporosis in Asian Women

Park H, Yang H, Heo J, Jang HW, Chung JH, Kim TH, Min YK, Kim SW

Background: Bone mineral density (BMD) testing is indicated for women aged 65 years, but screening strategies for osteoporosis are controversial. Currently, there is no study focusing on the BMD testing...
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Real-World Safety and Effectiveness of Denosumab in Patients with Osteoporosis: A Prospective, Observational Study in South Korea

Rhee Y, Chang DG, Ha J, Kim S, Lee Y, Jo E, Koh JM

Background: The efficacy and safety of denosumab have been established in a phase 3, randomized, placebo-controlled trial in Korean postmenopausal women with osteoporosis. This postmarketing surveillance study was aimed to...
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Identification of Healthy and Unhealthy Lifestyles by a Wearable Activity Tracker in Type 2 Diabetes: A Machine Learning-Based Analysis

Kim KJ, Lee JB, Choi J, Seo JY, Yeom JW, Cho CH, Bae JH, Kim SG, Lee HJ, Kim NH

Lifestyle is a critical aspect of diabetes management. We aimed to define a healthy lifestyle using objectively measured parameters obtained from a wearable activity tracker (Fitbit) in patients with type...
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Sestrin2 Regulates Beneficial β3-Adrenergic Receptor-Mediated Effects Observed in Inguinal White Adipose Tissue and Soleus Muscle

Park MJ, Kim JW, Roh E, Choi KM, Baik SH, Hwang HJ, Yoo HJ

Sestrin2, a well-known adenosine monophosphate-activated protein kinase (AMPK) regulator, plays a protective role against metabolic stress. The β3-adrenergic receptor (β3AR) induces fat browning and inhibits muscle atrophy in an AMPK-dependent...
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Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research

Kim JH, Yu SM, Son JW

Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle...
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Euthyroid Thyroperoxidase Antibody Positivity during Pregnancy, to Treat or Not to Treat?

Korevaar TIM

Thyroperoxidase antibody (TPOAb) positivity is a well-known risk factor for thyroid dysfunction during pregnancy and is associated with a suboptimal response to thyroidal stimulation by human chorionic gonadotropin. About 75%...
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Improvement in Age at Mortality and Changes in Causes of Death in the Population with Diabetes: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018

Han E, Song SO, Kim HS, Son KJ, Jee SH, Cha BS, Lee BW

Background: Diabetes is a leading cause of death that is responsible for 1.6 million annual deaths worldwide. However, the life expectancy and age at death of people with diabetes have...
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Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer

Kasarla SS, Garikapati V, Kumar Y, Dodoala S

Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past few decades. However, the proportion of the active form of vitamin...
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Association between the Blautia/Bacteroides Ratio and Altered Body Mass Index after Bariatric Surgery

Kim Y, Son D, Kim BK, Kim KH, Seo KW, Jung K, Park SJ, Lim S, Kim JH

Background: Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease the risk of life-threatening weight-related health problems and...
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Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer

Hoang T, Lee EK, Lee J, Hwangbo Y, Kim J

Background: This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid...
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Short-Chain Fatty Acids Attenuate Renal Fibrosis and Enhance Autophagy of Renal Tubular Cells in Diabetic Mice Through the HDAC2/ULK1 Axis

Ma X, Wang Q

Background: This study investigated the effect of short-chain fatty acids (SCFAs) on diabetes in a mouse model. Methods: Autophagy in Akita mice and streptozocin (STZ)-induced diabetic C57BL/6 mice was determined by...
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Effect of the Concomitant Use of Subcutaneous Basal Insulin and Intravenous Insulin Infusion in the Treatment of Severe Hyperglycemic Patients

Lim Y, Ohn JH, Jeong J, Ryu J, Kim Sw, Cho JH, Park HS, Kim HW, Lee J, Kim ES, Kim NH, Jo YH, Jang HC

Background: No consensus exists regarding the early use of subcutaneous (SC) basal insulin facilitating the transition from continuous intravenous insulin infusion (CIII) to multiple SC insulin injections in patients with...
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Clinical Outcomes of Repeated Radioactive Iodine Therapy for Graves’ Disease

Kim MJ, Cho SW, Kim YA, Choi HS, Park YJ, Park DJ, Cho BY

Background: Radioactive iodine (RAI) therapy is a successful therapeutic modality for Graves’ disease. However, RAI therapy can fail, and RAI therapy after antithyroid drugs (ATDs) has a lower remission rate....
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Fancd2os Reduces Testosterone Production by Inhibiting Steroidogenic Enzymes and Promoting Cellular Apoptosis in Murine Testicular Leydig Cells

Zhai X, Li Xy, Wang Yj, Qin Kr, Hu Jr, Li Mn, Wang Hl, Guo R

Background: It is well-established that serum testosterone in men decreases with age, yet the underlying mechanism of this change remains elusive. Methods: The expression patterns of Fancd2 opposite-strand (Fancd2os) in BALB/c...
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