Endocrinol Metab.  2022 Jun;37(3):506-512. 10.3803/EnM.2022.1429.

Bone Mineral Density Screening Interval and Transition to Osteoporosis in Asian Women

• Park H
• Yang H
• Heo J
• Jang HW
• Chung JH
• Kim TH
• Min YK
• Kim SW

• KMID: 2531394
• DOI: http://doi.org/10.3803/EnM.2022.1429

Abstract

Background
Bone mineral density (BMD) testing is indicated for women aged 65 years, but screening strategies for osteoporosis are controversial. Currently, there is no study focusing on the BMD testing interval in Asian populations. The current study aimed to evaluate the estimated time interval for screening osteoporosis.
Methods
We conducted a study of 6,385 subjects aged 50 years and older who underwent dual-energy X-ray absorptiometry screening more than twice at Samsung Medical Center as participants in a routine health checkup. Subjects were divided based on baseline T-score into mild osteopenia (T-score, <–1.0 to >–1.5), moderate osteopenia (T-score, ≤–1.5 to >–2.0), and severe osteopenia (T-score, ≤–2.0 to >–2.5). Information about personal medical and social history was collected by a structured questionnaire.
Results
The adjusted estimated BMD testing interval for 10% of the subjects to develop osteoporosis was 13.2 years in mild osteopenia, 5.0 years in moderate osteopenia, and 1.5 years in severe osteopenia.
Conclusion
Our study provides extended information about BMD screening intervals in Asian female population. Baseline T-score was important for predicting BMD screening interval, and repeat BMD testing within 5 years might not be necessary in mild osteopenia subjects.

Keyword

Bone density; Screening interval; Bone diseases, metabolic; Osteoporosis

Figure

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  Fig. 1. Study population. DXA, dual-energy X-ray absorptiometry; BMD, bone mineral density; GFR, glomerular filtration rate.

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  Fig. 2. Unadjusted cumulative incidence curve of osteoporosis according to baseline T-score.

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