- Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma
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Song HJ, Shim KN, Joo YH, Kim SE, Jung SA, Yoo K
- KMID: 2135130
- Gut Liver.
- 2008 Sep;2(2):119-125.
BACKGROUND/AIMS: RUNX3 (PEBP2alphaC/CBFA3/AML2) is a novel tumor suppressor gene in the human gastric carcinoma. The aims of this study were to determine the methylation of RUNX3 promoter and the association... -
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- An Inverse Relationship between the Expression of the Gastric Tumor Suppressor RUNX3 and Infection with Helicobacter pylori in Gastric Epithelial Dysplasia
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Chung WC, Jung SH, Joo KR, Kim MJ, Youn GJ, Kim Y, Lee JS, Lee H, Jung JH, Lee YK
- KMID: 1712329
- Gut Liver.
- 2013 Nov;7(6):688-695.
BACKGROUND/AIMS: This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions. METHODS: We examined 107 patients with gastric epithelial dysplasia who had... -
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- The Causal Relationship between RUNX3 and Bladder Tumor
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Kim EJ, Kim WJ
- KMID: 2293832
- Korean J Urol.
- 2005 Nov;46(11):1192-1198.
PURPOSE: We investigated the methylation pattern of RUNX3 to determine whether aberrant methylation events are risk factors for bladder tumor development, recurrence, and progression. MATERIALS AND METHODS: A hospital based, case-control... -
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- Epigenetic inactivation of RUNX3 in colorectal cancer
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Shin EJ, Kim HJ, Son MW, Ahn TS, Lee HY, Lim DR, Bae SB, Jeon S, Kim H, Jeong D, Lee MS, Kim DS, Noh JS, Baek MJ
- KMID: 2405335
- Ann Surg Treat Res.
- 2018 Jan;94(1):19-25.
- doi: 10.4174/astr.2018.94.1.19
PURPOSE: Emerging evidence indicates that runt-related transcription factor 3 (RUNX3) is an important tumor suppressor gene in several cancer types, including colorectal cancer (CRC). However, the clinical significance of RUNX3... -
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- RUNX3 Methylation, Loss of RUNX3 Expression and Clinicopathologic Findings according to Helicobacter pylori CagA in Gastric Carcinoma
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Na YJ, Shim KN, Joo YH, Kim SE, Jung HK, Jung SA, Cho MS
- KMID: 2373318
- Korean J Gastroenterol.
- 2015 Aug;66(2):75-84.
- doi: 10.4166/kjg.2015.66.2.75
BACKGROUND/AIMS: Helicobacter pylori cytotoxin-associated gene A (CagA) has been suggested to be involved in the inactivation of Runt-related transcription factor 3 (RUNX3), a known gastric carcinoma tumor suppressor gene. It... -
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- Downregulation of the RUNX3 Gene by Promoter Hypermethylation and Hemizygous Deletion in Breast Cancer
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Hwang KT, Han W, Bae JY, Hwang SE, Shin HJ, Lee JE, Kim SW, Min HJ, Noh DY
- KMID: 1785785
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S24-S31.
- doi: 10.3346/jkms.2007.22.S.S24
The RUNX3 gene is regarded as a tumor suppressor gene in many human solid tumors, and its inactivation is believed to be related with solid tumor carcinogenesis. As little information... -
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