- Phylogenetically interrelated ETS genes, ETV1, ERM and E1A-F locate on different chromosomes
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Jeon IS, Shapiro DN
- KMID: 1038161
- J Korean Med Sci.
- 1998 Aug;13(4):355-360.
- doi: 10.3346/jkms.1998.13.4.355
ETV1, ERM and E1A-F are members of the multigene ETS domain containing a class of transcription factors, first identified in the genome of the avian retrovirus E26. Based upon... -
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- B-cell Acute Lymphoblastic Leukemia With t(9;22)(q34;q11) Translocation and Clonal Divergence Through ider(22) Chromosome and t(13;17)(q14;q25) Translocation
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Meza-Espinoza JP, Romo Martinez EJ, Aguilar Lopez L, Picos Cardenas VJ, Magana Torres MT, Gonzalez Garcia JR
- KMID: 2373523
- Ann Lab Med.
- 2016 Mar;36(2):185-187.
- doi: 10.3343/alm.2016.36.2.185
No abstract available. -
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- Detection of PML/RARA Rearrangement by Reverse Transcriptase-PCR and Sequencing in a Case of Microgranular Acute Promyelocytic Leukemia Lacking t(15;17) on Karyotype and FISH
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Kim KE, Woo KS, Kim SH, Han JY
- KMID: 1077411
- Korean J Lab Med.
- 2009 Oct;29(5):379-383.
- doi: 10.3343/kjlm.2009.29.5.379
We report a case of morphologically microgranular acute promyelocytic leukemia with PML/RARA fusion transcripts demonstrated by reverse transcriptase-PCR and cDNA sequencing, and no PML/RARA fusion detected by karyotype and FISH... -
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- A Family of Charcot-Marie-Tooth 1A Confirmed by Molecular Genetic Analysis
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Choi BO, Sunwoo IN, Lee JS, Bae JC
- KMID: 1659740
- J Korean Neurol Assoc.
- 1996 Dec;14(4):1023-1029.
Recently, thanks to the development of the molecular genetics which had made us understand the nature of some genetic disorders, the concept of the classification has changed. Charcoal-Marie-Tooth disease (CMT)... -
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- t(12;17)(p13;q12)/TAF15-ZNF384 Rearrangement in Acute Lymphoblastic Leukemia
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Kim J, Kim HS, Shin S, Lee ST, Choi JR
- KMID: 2373567
- Ann Lab Med.
- 2016 Jul;36(4):396-398.
- doi: 10.3343/alm.2016.36.4.396
No abstract available. -
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- Identification of marker chromosomes by reverse painting fluorescence in situ hybridization and comparative genomic hybridization
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Kang JK, Cho YH, Kyhm JH, Shin ES, Hoh JK, Chung SR
- KMID: 2272680
- Korean J Obstet Gynecol.
- 2005 Sep;48(9):2125-2139.
OBJECTIVE: Although marker chromosome is defined as an abnormal chromosome in which no part can be identified, derivative chromosomes with structural abnormalities of unknown origin are also called as marker... -
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- Loss of Heterozygosity on Chromosomes 3p,8p,9p and 17p in the Progression of Squamous Cell Carcinoma of the Larynx
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Yoo WJ, Cho SH, Lee YS, Park GS, Kim MS, Kim BK, Park WS, Lee JY, Kang CS
- KMID: 1786810
- J Korean Med Sci.
- 2004 Jun;19(3):345-351.
- doi: 10.3346/jkms.2004.19.3.345
Previous molecular genetic studies of laryngeal squamous cell carcinoma (SCC)have shown certain chromosomal regions with recurring alterations. But studies of sequential molecular alterations and genetic progression model of laryngeal SCC... -
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- Novel PML-RARA Fusion Gene on Chromosome 17 in Acute Promyelocytic Leukemia with Normal Chromosome 15 and 17
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Kim KH, Won JH, Jeung KJ, Lee SC, Kim HJ, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Park HS, Lee YK
- KMID: 2305207
- Korean J Hematol.
- 2007 Sep;42(3):296-300.
- doi: 10.5045/kjh.2007.42.3.296
We describe a patient with acute promyelocytic leukemia (APL) with no detectable cytogenetic abnormality of either chromosomes 15 or 17 who nevertheless had juxtaposition of promyelocytic leukemia (PML) and retinoic... -
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- The t (15;17) Breakpoint of the PML Gene in Acute Promyelocytic Leukemia
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Park SS, Cho HI
- KMID: 2146191
- Korean J Clin Pathol.
- 1997 Dec;17(6):885-897.
BACKGROUND: The characteristic t(15; 17) of acute promyelocytic leukemia (APL) fuses the retinoic acid receptor alpha (RARA) gene on chromosome 17 to the PML gene on chromosome 15. The test... -
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- Loss of heterozygosity on chromosome 10, 13q(Rb), 17p, and p53 gene mutations in human brain gliomas
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Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Hong SI, Choi KS
- KMID: 927177
- J Korean Med Sci.
- 1995 Dec;10(6):442-448.
- doi: 10.3346/jkms.1995.10.6.442
Using the methods of restriction fragment length polymorphism (RFLP) and single strand conformation polymorphism (SSCP) analyses, we have examined 33 cases of human gliomas with various malignant grades to detect... -
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- A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
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Kim MJ, Cho SY, Lim G, Yoon HS, Lee HJ, Suh JT, Lee J, Lee WI, Cho KS, Park TS
- KMID: 1094345
- Korean J Lab Med.
- 2011 Apr;31(2):86-90.
- doi: 10.3343/kjlm.2011.31.2.86
We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a... -
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- Spectra of Chromosomal Aberrations in 325 Leukemia Patients and Implications for the Development of New Molecular Detection Systems
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Choi HJ, Kim HR, Shin MG, Kook H, Kim HJ, Shin JH, Suh SP, Ryang DW
- KMID: 1094259
- J Korean Med Sci.
- 2011 Jul;26(7):886-892.
- doi: 10.3346/jkms.2011.26.7.886
This study investigated the spectrum of chromosomal abnormalities in 325 leukemia patients and developed optimal profiles of leukemic fusion genes for multiplex RT-PCR. We prospectively analyzed blood and bone marrow... -
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- A Rare Case of Acute Lymphoblastic Leukemia with t(12;17)(p13;q21)
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Kim JE, Woo KS, Kim KE, Kim SH, Park JI, Shaffer LG, Han JY
- KMID: 1781621
- Korean J Lab Med.
- 2010 Jun;30(3):239-243.
- doi: 10.3343/kjlm.2010.30.3.239
Patients with ALL rarely present with t(12;17)(p13;q21) as the primary clonal abnormality; this abnormality is associated with the expression of myeloid antigens. In this study, we have reported presumably the... -
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- Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients
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Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Ozbek U
- KMID: 1093619
- Exp Mol Med.
- 2003 Oct;35(5):454-459.
All-trans retinoic acid (ATRA) treatment of the acute promyelocytic leukemia (APL) have subsequently resulted in cell apoptosis, but the molecular mechanism of this effect remains elusive. In order to understand... -
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- Loss of Heterozygosity on Chromosome 3p, 9p, 17p in Oral & Oropharyngeal Squamous Cell Carcinoma
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Lee SH, Kim MS, Sun DI, Song CJ, Cho SH
- KMID: 2274729
- Korean J Otolaryngol-Head Neck Surg.
- 2000 Jul;43(7):746-750.
BACKGROUND AND OBJECTIVES: Patients of oral and oropharyngeal squamous cell carcinoma in the comparable stage have diverse clinical courses and responses to similar treatment. Understanding the genetic alterations that occur... -
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- The effect of isochromosome 17q presence, proliferative and apoptotic indices, expression of c-erbB-2, bcl-2 and p53 proteins on the prognosis of medulloblastoma
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Nam DH, Wang KC, Kim YM, Chi JG, Kim SK, Cho BK
- KMID: 1730644
- J Korean Med Sci.
- 2000 Aug;15(4):452-456.
- doi: 10.3346/jkms.2000.15.4.452
Medulloblastoma accounts for 20 to 25+ACU- of all intracranial neoplasms in children. The significance of the presence of isochromosome 17q (i(17q)), proliferative potential, apoptotic activity, and expression of c-erbB-2, bd-2,... -
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- Real-Time PCR analysis of af4 and dek genes expression in acute promyelocytic leukemiat (15;17)patients
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Savli H, Sirma S, Nagy B, Aktan M, Dincol G, Salcioglu , Sarper N, Ozbek U
- KMID: 1097111
- Exp Mol Med.
- 2004 Jun;36(3):279-282.
Among several newly identified oncogenes, dek and af4 are attractive targets for researchers interested with leukemia. In this study quantitative Real-Time RT-PCR technique was used to define alterations in expression... -
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- Miller-Dieker Syndrome with der(17)t(12;17)(q24.33;p13.3)pat Presenting with a Potential Risk of Mis-identification as a de novo Submicroscopic Deletion of 17p13.3
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Kim YJ, Byun SY, Jo SA, Shin YB, Cho EH, Lee EY, Hwang SH
- KMID: 1096661
- Korean J Lab Med.
- 2011 Jan;31(1):49-53.
- doi: 10.3343/kjlm.2011.31.1.49
Miller-Dieker syndrome involves a severe type of lissencephaly, which is caused by defects in the lissencephaly gene (LIS1). We report the case of a female infant with der(17)t(12;17)(q24.33;p13.3)pat caused by... -
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- Prevalence of FLT3 Internal Tandem Duplication in Adult Acute Myelogenous Leukemia
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Lee JN, Kim HR, Shin JH, Joo YD
- KMID: 1781490
- Korean J Lab Med.
- 2007 Aug;27(4):237-243.
- doi: 10.3343/kjlm.2007.27.4.237
BACKGROUND: fms-like tyrosine kinase (FLT3), a member of the class III receptor tyrosine kinases, regulates the proliferation and differentiation of hematopoietic stem cells. An internal tandem duplication of the... -
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- A Case of 17q22 with Interstitial Deletion
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Kang SY, Lee BH, Kim GH, Choi JH, Yoo HW
- KMID: 1851092
- J Genet Med.
- 2011 Jun;8(1):58-61.
- doi: 10.5734/JGM.2011.8.1.58
Cases of interstitial deletions of the long arm of chromosome 17 are very rare, with only nine cases ever reported worldwide. We describe a 12-year-old boy with profound developmental delay,... -
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