Korean J Lab Med.
2011 Apr;31(2):86-90. 10.3343/kjlm.2011.31.2.86.
A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient
- Affiliations
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- 1Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. 153jesus@hanmail.net
- 2Department of Pediatrics, School of Medicine, Kyung Hee University, Seoul, Korea.
- 3Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea.
- 4Department of Hematology-Oncology, School of Medicine, Kyung Hee University, Seoul, Korea. ksamcho@khmc.or.kr
- KMID: 1094345
- DOI: http://doi.org/10.3343/kjlm.2011.31.2.86
Abstract
- We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.
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