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Stromal cell-derived factor-1 (SDF-1) expression in the oral squamous cell carcinoma

Kim KW, Han SJ, Roh KS

PURPOSE: Chemokines are structurally related, small polypeptide signaling molecules that bind to and activate a family of transmembrane G proteincoupled receptors, the chemokine receptors. Recently, interaction between the chemokine receptor...
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LPS-Induced Migration of Peritoneal B-1 Cells is Associated with Upregulation of CXCR4 and Increased Migratory Sensitivity to CXCL12

Moon H, Lee JG, Shin SH, Kim TJ

B-1 cells, which constitute a predominant lymphocyte subset in serosal cavities and produce most of natural antibodies, are subdivided into the CD5+ B-1a and CD5- B-1b cell subpopulations, but the...
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Cell Versus Chemokine Therapy Effects on Cell Mobilization to Chronically Dysfunctional Urinary Sphincters of Nonhuman Primates

Williams J, Mariya S, Suparto I, Lankford S, Andersson

PURPOSE: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs....
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Chemokine and Chemokine Receptor Polymorphisms in Bipolar Disorder

Tokac D, Tuzun E, Gulec H, Yılmaz V, Bireller E, Cakmakoglu B, Kucukali C

OBJECTIVE: Bipolar disorder (BD) is a debilitating psychiatric disease with unknown etiology. Recent studies have shown inflammation as a potential contributing factor of BD pathogenesis. However, potential associations between chemokine...
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Expression of CXCR4 and SDF-1alpha in Primary Breast Cancers and Metastatic Lymph Nodes

Kim JO, Suh KS, Lee DH, Sul HJ, Lee JU, Song KS

PURPOSE: A CXCR4/stroma derived factor-1alpha (SDF-1alpha, CXCL12) interaction is involved in many metastatic cancer mechanisms, including breast cancer. The primary objectives of this study were to investigate the correlation between...
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Stromal-cell-derived Factor 1-alpha Promotes Tumor Progression in Colorectal Cancer

Park SJ, Ahn TS, Cho SW, Kim CJ, Jung DJ, Son MW, Bae SH, Shin EJ, Lee MS, Kim CH, Baek MJ

PURPOSE: Although stromal-cell-derived factor (SDF)-1alpha is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined...
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Preparation and Characterization of SDF-1alpha Recombinant Adenovirus for ex vivo Expansion of Hematopoietic Stem Cells

Joo EK, Jo DY, Joo JH, Myung PK, Lee Y

  • KMID: 2168480
  • J Bacteriol Virol.
  • 2005 Mar;35(1):39-47.
Stromal cell-derived factor 1 (SDF-1/CXCL12) is a multifunctional cytokine implicated in normal hematopoiesis. We previously reported that SDF-1alpha enhanced the survival of hematopoietic stem and progenitor cells in synergy with...
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Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis

Song JS, Kang CM, Kang HH, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH

CXC chemokine receptor 4 (CXCR4), which binds the stromal cell-derived factor-1 (SDF-1), has been shown to play a critical role in mobilizing the bone marrow (BM)-derived stem cells and inflammatory...
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Serological Predictors for the Recurrence of Atrial Fibrillation After Electrical Cardioversion

Kim SK, Pak HN, Park JH, Ko KJ, Lee JS, Wi J, Choi JI, Kim YH

BACKGROUND AND OBJECTIVES: Although electrical cardioversion (CV) is effective in restoring sinus rhythm (SR) in patients with atrial fibrillation (AF), AF frequently recurs in spite of antiarrhythmic medications. We investigated...
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High Frequencies of the CCR2b-64I and SDF1-3'A Mutations with HIV Infection in Koreans

Choi BS, Cha SH, Kim SS, Park YK, Lee JS

BACKGROUND: Host genetic polymorphisms in the HIV-1 co-receptor CCR5 and CCR2b and SDF-1, ligand for co-receptor CXCR4, have been known to be associated with the resistance of HIV infection and/or...
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Macrophage Migration Inhibitory Factor (MIF) Induced Stromal Cell-derived Factor 1 (SDF-1) Production Via Nuclear Factor KappaB (NF-kappaB) Signaling in Rheumatoid Arthritis Fibroblast Like Synoviocytes (RA-FLS)

Cho ML, Park MK, Kim KW, Oh HJ, Lee SY, Park JS, Heo YJ, Ju JH, Min JK, Lee SH, Park SH, Kim HY

BACKGROUND: Stromal cell-derived factor (SDF)-1 is a potent chemoattractant for activated T cells into the inflamed Rheumatoid arthritis (RA) synovium. To determine the effect of macrophage migration inhibitory factor (MIF)...
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Cytoplasmic Domain of Intercellular Adhesion Molecule-1(ICAM-1)is Important for the ICAM-1 Mediated Membrane Projection of Endothelial Cells

Seo GS, Choi M, Oh HM, Lee MH, Lee KM, Nah YH, Jun CD

  • KMID: 2030767
  • Korean J Anat.
  • 2005 Feb;38(1):11-19.
Intercellular adhesion molecule-1 (ICAM-1)has been shown to enhance leukocyte adhesion, thereby inducing migration through blood endothelial cells. However, the molecular event during the process of adhesion is largely unknown. To...
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Expression of SDF-1alpha and leptin, and their effect on expression of angiogenic factors in mouse ovaries

Park MJ, Park SH, Lee SK, Moon SE, Moon HS, Joo BS

OBJECTIVE: Ovarian angiogenesis plays an important role in folliculogenesis. However, little is known about the expression of angiogenic factors during follicular development according to female age. Stromal cell derived factor-1alpha...
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Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models

Park GT, Kim SU, Choi KC

PURPOSE: Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells...
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Effect of Endogenous Bone Marrow Derived Stem Cells Induced by AMD-3100 on Expanded Ischemic Flap

Jeong HS, Lee HK, Tark KC, Lew DH, Koh YW, Kim CH, Seo IS

The purpose of this study was to devise an expanded ischemic flap model and to investigate the role of AMD-3100 (Plerixafor, chemokine receptor 4 inhibitor) in this model by confirming...
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Histological and Biochemical Comparisons between Right Atrium and Left Atrium in Patients with Mitral Valvular Atrial Fibrillation

Park JH, Lee JS, Ko YG, Lee SH, Lee BS, Kang SM, Chang BC, Pak HN

BACKGROUND AND OBJECTIVES: It has been known that the dominant driver of atrial fibrillation (AF) exists in the left atrium (LA) and the incidence of systemic thromboembolism is higher than...
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Effects of Intracoronary Administration of Autologous Adipose Tissue-Derived Stem Cells on Acute Myocardial Infarction in a Porcine Model

Lee HW, Lee HC, Park JH, Kim BW, Ahn J, Kim JH, Park JS, Oh JH, Choi JH, Cha KS, Hong TJ, Park TS, Kim SP, Song S, Kim JY, Park MH, Jung JS

PURPOSE: Adipose-derived stem cells (ADSCs) are known to be potentially effective in regeneration of damaged tissue. We aimed to assess the effectiveness of intracoronary administration of ADSCs in reducing the...
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