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Chemotherapy for Advanced Gastric Cancer: Review and Update of Current Practices

Park SC, Chun HJ

  • KMID: 1806634
  • Gut Liver.
  • 2013 Jul;7(4):385-393.
No standard adjuvant or palliative chemotherapy regimen has been internationally approved for patients with advanced gastric cancer. Adjuvant chemoradiotherapy is administered prior to surgery and is used in the Unitied...
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Complete biologic response to taxane based chemotherapy confirmed by [18F]FDG PET/CT and surgery in a cancer of unknown primary site

Hwang JE, Yoon JY, Bae WK, Shim HJ, Chung IJ

Cancers of an unknown primary site are heterogenous with respect to their clinical and pathologic features. They are generally very aggressive, but specific favorable subsets have a better prognosis. For...
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Symptom and Interference of Activities of Daily Living of Chemotherapy-Induced Peripheral Neuropathy in Patients Receiving Taxanes and Platinums

Kim JH, Lee KM, Jeon MJ, Seol ME, Lee SH, Park J

PURPOSE: The purpose of this study was to identify the symptoms and interference of activities of daily living (ADL) of chemotherapy induced peripheral neuropathy (CIPN) in patients receiving taxane and...
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MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma

Park PE, Jeong JY, Kim SZ, Park JY

  • KMID: 2141002
  • Korean J Pathol.
  • 2013 Oct;47(5):418-425.
BACKGROUND: Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to...
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Chemotherapy Response Assay Test and Prognosis for Breast Cancer Patients Who Have Undergone Anthracycline- and Taxane-Based Chemotherapy

Lee A, Lim W, Moon BI, Paik NS, Koh SH, Song JY

PURPOSE: A chemotherapy response assay test is performed to evaluate the degree of tumor growth inhibition by a chemotherapeutic agent. Several studies have been done on its usefulness; however, to...
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Prognostic Factors of Second and Third Line Chemotherapy Using 5-FU with Platinum, Irinotecan, and Taxane for Advanced Gastric Cancer

Park JS, Lim JY, Park SK, Kim MK, Ko HS, Yoon SO, Kim JW, Choi SH, Cho JY

  • KMID: 2167566
  • Cancer Res Treat.
  • 2011 Dec;43(4):236-243.
PURPOSE: The aims of this study are to find out whether the sequence of chemotherapeutic regimens including second- and third-line taxane and irinotecan influences the survival of patients with unresectable...
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A feasibility study on maintenance of docetaxel after paclitaxel-carboplatin chemotherapy in patients with advanced ovarian cancer

Isonishi S, Suzuki M, Nagano H, Takagi K, Shimauchi , Kawabata M, Ochiai K

OBJECTIVE: To test the concept of taxane sequencing, this feasibility trial evaluated maintenance of docetaxel after paclitaxel and carboplatin combination chemotherapy in patients with stage IC-IV ovarian cancer. METHODS: All patients...
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Investigating Effective Combinations of Anti-cancer Drugs and Radiation Therapy for Treating Non-small Cell Lung Cancer with Using Two Cell Lines

Oh IJ, Cho HJ, Manaljav T, Kwon YS, Kim KS, Lim SC, Kim YC, Ahn SJ

PURPOSE: Radiotherapy had been used for treating unresectable locally advanced non-small cell lung cancer (NSCLC). However, the survival rate after radiotherapy alone is low and this primarily due to the...
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Phase II Study of Gemcitabine plus Cisplatin in Patients with Anthracycline- and Taxane- Pretreated Metastatic Breast Cancer

Kim JH, Oh SY, Kwon HC, Lee S, Kim SH, Kim DC, Lee JH, Lee HS, Cho SH, Kim HJ

  • KMID: 1804609
  • Cancer Res Treat.
  • 2008 Sep;40(3):101-105.
PURPOSE: Metastatic breast cancer patients are usually exposed to taxane and anthracycline as neoadjuvant, adjuvant and palliative chemotherapeutic agents. This study was designed to determine the efficacy and safety of...
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Risk stratification of abdominopelvic failure for FIGO stage III epithelial ovarian cancer patients: implications for adjuvant radiotherapy

Chang JS, Koom WS, Kim SW, Kim S, Kim YB, Kim YT, Kim GE

OBJECTIVE: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian...
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Phase II Study of Vinorelbine Plus Ifosfamide in Patients with Taxane-resistant Metastatic Breast Cancer

Lee S, Oh SY, Kwon HC, Kim SH, Kwon KA, Hsing CT, Kim DC, Lee JH, Lee HS, Lee MR, Cho SH, Kim HJ

PURPOSE: The patients with metastatic breast cancer are routinely exposed to taxane and anthracycline as neoadjuvant, adjuvant, and palliative chemotherapeutic agents. This study was designed to evaluate the efficacy and...
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Efficacy of taxane and platinum-based chemotherapy guided by extreme drug resistance assay in patients with epithelial ovarian cancer

Joo WD, Lee JY, Kim JH, Yoo HJ, Roh HJ, Park JY, Kim DY, Kim YM, Kim YT, Nam JH

OBJECTIVE: To evaluate the efficacy of taxane and platinum-based chemotherapy guided by extreme drug resistance assay (EDRA) in patients with epithelial ovarian cancer. METHODS: Thirty-nine patients were enrolled, who were diagnosed...
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Radiation-induced Pulmonary Toxicity and Related Risk Factors in Breast Cancer

Kim HJ, Jang WI, Kim TJ, Kim JH, Kim SW, Moon SH, Kim JS, Kim IA

PURPOSE: This study was designed to assess the incidence of pulmonary toxicity (PT) and related risk factors in breast cancer patients treated with postoperative adjuvant radiotherapy (RT) with or without...
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Phase II Study of Irinotecan, High-dose 5-fluorouracil, and Leucovorin Combination Chemotherapy in Taxane and Cisplatin-based Chemotherapy-refractory Metastatic Gastric Cancer

Yoon JY, Lee SJ, Cho DH, Rew SY, Kim DE, Hwang JE, Bae WK, Shim HJ, Cho SH, Chung IJ

This phase II study evaluated the efficacy and safety of combination chemotherapy with irinotecan, high-dose 5-fluorouracil (5-FU), and leucovorin as a second line of treatment in metastatic gastric cancer refractory...
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Gemcitabine and Vinorelbine Combination Chemotherapy in Anthracycline- and Taxane-pretreated Advanced Breast Cancer

Kim HJ, Kim JS, Seo MD, Oh SY, Oh DY, Kim JH, Lee SH, Kim DW, Im SA, Kim TY, Heo DS, Bang YJ

  • KMID: 2166006
  • Cancer Res Treat.
  • 2008 Jun;40(2):81-86.
PURPOSE: Anthracycline and taxanes are effective agents in advanced breast cancer and prolong survival times. Some patients achieve prolongation of life with capecitabine, gemcitabine, or vinorelbine, even after failure of...
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D60-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation

Kim JG, Shin IC, Lee KS, Han JS

  • KMID: 1457546
  • Exp Mol Med.
  • 2001 Dec;33(4):303-309.
Both Fas and PMA can activate phospholipase D via activation of protein kinase Cbeta in A20 cells. Phospholipase D activity was increased 4 fold in the presence of Fas and...
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Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways

Lim JH, Um HJ, Park JW, Lee IK, Kwon TK

Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this...
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